DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and CG16727

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	158/554 - (28%)
Similarity:	256/554 - (46%)	Gaps:	71/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCAL-------PYENGSI 58
            |.:|.|:...|.||.:|..|..|.....|:.:.|..:...:...|:..|:.       ..|..||
  Fly     1 MDFDRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHDDLMGLGAAELRSI 65

  Fly    59 YELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLV 123
            |.      |:|:|.   |:     ...|.:||:...|.   ::|..::::|.....|..||...|
  Fly    66 YS------NVSHPS---CT-----LLSEVINGTGVASE---ESCQDWIFERENGYESLTTELKWV 113

  Fly   124 CSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFS----- 183
            |.:|...|...|.|.||.::|::.||.:||.:||.|.        ::...|:....::.:
  Fly   114 CDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPA--------MLMAALSGATGDFITSFVHT 170

  Fly   184 ---YTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFA-GVAMQMFFSVGFMLTAGFAYFIHDWR 244
               :..||.:.|.:|..::.:.|::..|.:....|.|. .:.:.:|:..|.|.:...|.:|.:||
  Fly   171 LPWFAFSRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWR 235

  Fly   245 ---WLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDE 306
               ||   .:||.|..|.|..:|.|||:|||.|.:.|||...::|.||.|..:|.:.::::.|..
  Fly   236 RYLWL---ASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKH 297

  Fly   307 VAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFM 371
            ..| |..:|...::...|...:.:.|.|||.|..:.....:.:..|..::.|...||.:....|.
  Fly   298 YRE-KMNEESKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFS 361

  Fly   372 ISGAVEIP-GYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFV-----PSDMNWLIVACAMIGK 430
            ::.:|.:| |:|:||.. |:.||:.:.||.::|..|....|.|:     ||:...|:.....:|:
  Fly   362 LTSSVYLPAGFTILLLQ-NKIGRKGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGR 425

  Fly   431 LAITSSYGTIYIFSAEQFPTVVRN--------VGLGASSMVARVGGILAPYLKLLGEIWRPLPLI 487
            ...|.||.....::||..||.||.        |||.:||        ||.|:..|.:.::|||.|
  Fly   426 FGTTVSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSS--------LAFYVIYLAQYYKPLPSI 482

  Fly   488 ICGALSLTAGLLSLLLPETLNKPMPETIEDGENF 521
            ....|.....||.|.|||||:|.:|||:.|||.|
  Fly   483 FISVLMFLGALLCLTLPETLHKKLPETLADGERF 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	149/535 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	107/381 (28%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	149/535 (28%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	111/394 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458407
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990