DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and CG6126

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	208/535 - (38%)
Similarity:	291/535 - (54%)	Gaps:	37/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNL 68
            :|::..|||||.||...::|..|..:....|.|:.|.:.|.|:.||.:...:.|...::|  ||.
  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTP--WNS 70

  Fly    69 S-----YP-----ENERCSYYDVDYTEEYLNGSIPRS--SNETKTCSSYVYDRSKYLNSAVTEWN 121
            |     .|     |.|.|..:|            |.|  :|.|..|..||||.:.|..|...:||
  Fly    71 SAILAAIPLKPNGELESCLMFD------------PSSPGTNTTINCERYVYDTTYYKTSRTIDWN 123

  Fly   122 LVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTI 186
            .||.|..:.|...::|||||..|::..|.::||:|||..|..|.:.|||.||..|..|||||:.:
  Fly   124 FVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMV 188

  Fly   187 SRMIVGAT-TSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAI 250
            :|.::|.. ::|.::..:|:.:|:||.:.|...|:..|..|:.|.||.||:...|.|.:|||:..
  Fly   189 ARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVIY 253

  Fly   251 TLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVP--NEIYEQLVDEVAEKKKQ 313
            .|.|.|||.::|.:.||.|||.|:||..||..|:.|..:.|...:|  .|.|.|       |.||
  Fly   254 GLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQ-------KAKQ 311

  Fly   314 DEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEI 378
            ...|..:.:|.:.||.|.||||.|||.:...||.||.||||||.:...|.||..:...|.|.||.
  Fly   312 QAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEF 376

  Fly   379 PGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIF 443
            |.|..::|.|:|.|||||....|:..|:..:...:: :..:....|..|.|||.|..|:..||.:
  Fly   377 PSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYI-AQGSTTSTAVVMAGKLLIAGSFAVIYNY 440

  Fly   444 SAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLN 508
            |||.|||||||..:|..||.||:.|.|.|.:.||......:|.::.|.::|.:|...:.||||:|
  Fly   441 SAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMN 505

  Fly   509 KPMPETIEDGENFGK 523
            :||||:|||||||||
  Fly   506 QPMPESIEDGENFGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	196/517 (38%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	143/358 (40%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	195/516 (38%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	147/378 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	9	9.100