DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a4

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	556	Identity:	181/556 - (32%)
Similarity:	289/556 - (51%)	Gaps:	40/556 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWN 67
            |||:.:.||.:||:|..::..|.:..:...|..|..||:...|...|.:|.:    ..:|....:
Zfish     4 YDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQ----INISSVWRD 64

  Fly    68 LSYP--------ENERCSYYDVD---------YTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLN 114
            .:.|        :...||.|.:|         ||.   |..:..|..||:.| ..:.|.:..|.:
Zfish    65 AAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTP---NVEVNLSQIETEPCVDGWSYSQEFYQS 126

  Fly   115 SAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAP 179
            :.||||:|||.|......:.|::..|||:|:.:.|||||:.||:|..|..:.||.|..::...:|
Zfish   127 TIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSP 191

  Fly   180 EYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAGFAYFIHDW 243
            .:..::.....||.:....::||||:..|::..:.| ||..:.:.|...:|.|.....||||..|
Zfish   192 SWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRSW 256

  Fly   244 RWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQL-VDEV 307
            |||.:...|.|||:...:|.||||.||||.:||..||..::.:||::|:|..|..|:... ::|.
Zfish   257 RWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIFSSSEIEEA 321

  Fly   308 AEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMI 372
            |:|:.|..        ::.|:|...|.....|:....|.|.:..||.|..||.||.||..:||.:
Zfish   322 AKKRIQKH--------SILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNFFL 378

  Fly   373 SGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSY 437
            |..||:|.|.:....|....||.....|:::.|..:.....:|:::..|..|..|:|||.:|:::
Zfish   379 SAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEMLGKLCVTAAF 443

  Fly   438 GTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLL 502
            ..:|..::|.|||||||:.:|:.||.||:|.|::|::..||..:|.:|.|:.|.|:|.:|::|||
Zfish   444 CVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIGGLALFSGVMSLL 508

  Fly   503 LPETLNKPMPETIED-----GENFGKKPAPQETAEE 533
            |||:..|.:||||..     |....:||....|.::
Zfish   509 LPESKGKVLPETIAQMQSVRGLRRCRKPPAASTEDK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	170/522 (33%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	123/357 (34%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	170/522 (33%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	130/373 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870