DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and slc22a7b.1

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_021322800.1	Gene:	slc22a7b.1 / 393320	ZFINID:	ZDB-GENE-040426-1311	Length:	560	Species:	Danio rerio

Alignment Length:	548	Identity:	165/548 - (30%)
Similarity:	288/548 - (52%)	Gaps:	28/548 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYEL-SPH 64
            |.:|:::.....||.||..:..||.:|.|....|.|...|:.|.|...|       .|..| :..
Zfish    11 MKFDNILDETDGFGRYQIALVMLLFIPRITIPCHFLLNNFIAAIPSHHC-------DISSLDADG 68

  Fly    65 LWNL--------SYPENE-----RCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSA 116
            |.||        |.|..|     .|..:.....:..:|.|...:....:..:.:.:|.|.::::.
Zfish    69 LGNLTQKERLIVSVPAQEDGTPASCHMFAHPQFQLLINSSSSSALPVVECQNGWHFDNSTFISTL 133

  Fly   117 VTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEY 181
            .|:::|||.:..|:..|.::|.:||:.|::.||.:.||.||:.....|.|..::|.|.:|.:..|
Zfish   134 ATQFDLVCDKRGLAKASATIFFVGVMCGAVFFGVLCDKYGRRSMLLVSYVFSIVFSVTSAFSSSY 198

  Fly   182 FSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWL 246
            ..:...|.:.|...:|:..::.|:::|.|.:.:|.|.|:...|.:|:|.||.||||:.:.|||.|
Zfish   199 IMFAAFRFLTGLALTGISNISVVLSIEWVDTKHRTFMGLFGSMSWSIGNMLLAGFAFMVTDWRLL 263

  Fly   247 QIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKEN-KVEVPNEIYEQLVDEVAEK 310
            .:.:|.|..|....:|.||:|||||:..|:.:.|:..:.|.|..| :::..:.:..:.:..|...
Zfish   264 IVIVTAPLFLATATWWWIPDSARWLIANGKTETAYKYLHKCATFNQRLDFTSRVKPETLSTVVTV 328

  Fly   311 KKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGA 375
            ..:..      :.|..||::.|.||:.||.....|:..:..|||:|.|....|.:..:...|..|
Zfish   329 DHRGH------SYTYLDLVKTPQLRKLTLFTGIVWYGVASTYYGISLNITGFGLDPYLTHFIYAA 387

  Fly   376 VEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTI 440
            :|:|...|:.|:||:.|||:...||:::.|..:|..|..|::........|::||....:|:.|:
Zfish   388 IEVPAKILVYFSLNKVGRRNTQTGTLVLTGFCILINIITPTEYWTFRTVIAVLGKGLSEASFTTV 452

  Fly   441 YIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPE 505
            .:::.|.:|||:|..|||.::.:||:|..::|.:.||.:||:.||.:|..::::..|:::|||||
Zfish   453 ILYTTELYPTVMRQNGLGFTNFMARMGASISPLIMLLEDIWKLLPEVIFCSMAIFCGIIALLLPE 517

  Fly   506 TLNKPMPETIEDGENFGKKPAPQETAEE 533
            |.|..:|||:||.|:..|||....||::
Zfish   518 TNNASLPETVEDIEDMRKKPVYFTTADQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	153/517 (30%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	111/356 (31%)
slc22a7b.1	XP_021322800.1	Sugar_tr	22..526	CDD:331684	153/516 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.980