DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and SLC22A25

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	587	Identity:	163/587 - (27%)
Similarity:	275/587 - (46%)	Gaps:	68/587 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQ-KRIYYLLCLPAIVCAFHKLA----GVFLLAKPDFRCALP-YENGSIY 59
            |.:.|::..:|..|.:| .::.:|:....||  :|:..    ..|:|   |.||.:. .:|.:|.
Human     1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVIV--YHQTQLENFAAFIL---DHRCWVHILDNDTIP 60

  Fly    60 ELSP------HLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRS 110
            :..|      .|..:|.|     ..|:| .:....:...:|||:.|.:|. :|:.| ..:|||:|
Human    61 DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQS 125

  Fly   111 KYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDK--------------------- 154
            .:.::.||:|:|||....|::.:..|||.|:::|..::|.:||:
Human   126 SFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPI 190

  Fly   155 ---------LGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMV 210
                     .|||.....|.:...|.|..||.||....|...|.:.||.|..:.:...::.:|.:
Human   191 AIHQHHVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWI 255

  Fly   211 GSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKG 275
            ...:...|........|:|.:.....|:.|.|...||:.::.|..:|..:...:.||||||::..
Human   256 THQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINN 320

  Fly   276 RKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLL 340
            :.:|....:.|||..|.::...:|   |..||.:...:.|:.|:|...::.:|||.||:.::...
Human   321 KPEEGLKELRKAAHRNGMKNAEDI---LTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICF 382

  Fly   341 IFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAG 405
            :.|..|.::..::||:.:..:||.|..:...:.|||.:....:..:.||...||......|.:..
Human   383 LSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLA 447

  Fly   406 ISLLATIFVPSDMNWLIVACAMIG----KLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARV 466
            ..|||.||||.:|..|.|..|.:|    .|.||.|...    ..|..|:::|....|.:...|.:
Human   448 TCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQ----ENELIPSIIRGRATGITGNFANI 508

  Fly   467 GGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFG--KKPAPQE 529
            ||.||..:.:|....||||.||.|..::.:||:.||||||.|:|:.::|:|.||.|  ...|||.
Human   509 GGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAAPQR 573

  Fly   530 TA 531
            ::
Human   574 SS 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	153/556 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	104/389 (27%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940