DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	550	Identity:	151/550 - (27%)
Similarity:	256/550 - (46%)	Gaps:	40/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGS-IYELSPHL- 65
            :..|:..:||||.:|.|:..|..:|:|:..|...:..|||.     ...||.|.| |.|:.|:|
Mouse    51 FASVMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLT-----AQRPYCNTSWILEVGPNLT 110

  Fly    66 ----WNLSYPENERCS------YYDVDYTEEYLNGSIPRSSNETKTCS-SYVYDRSKYLNSAVTE 119
                .||:.|.....|      |..|.:.   |:..|....|.|:||. .::|..: :..|.:.|
Mouse   111 EDEQLNLTLPRAPNGSFLTCLMYIPVPWD---LDSIIHFGLNYTETCKFGWIYPFA-HTRSLINE 171

  Fly   120 WNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSY 184
            ::|||..........::|:.|||.|||:||.:||||||.|....||:..||||...|....::.|
Mouse   172 FDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLLGFLIFGFGTAFVSSFYQY 236

  Fly   185 TISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIA 249
            ...|..|...:.|..:.:..:.:|.:...:|..|.:....|.::|.:|..|.||.:..||.|.:.
Mouse   237 LFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHSFLTIGVILLTGLAYKVVHWRLLCLL 301

  Fly   250 ITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQD 314
            ..:|....:|..|::.||.|||:::|:.:||..::..||:.||..:|..:..:|  :::.||
Mouse   302 GGMPMFPLICNIWVLRESPRWLMVRGKVEEAKKVLCYAAEVNKKTIPLNLLNEL--QISGKK--- 361

  Fly   315 EMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIP 379
                 ...|::.|.....:|.:..|.|...||..|.:.:.|:...|:.|.:.....|:...|.:|
Mouse   362 -----VAKASILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVYFVQMVRSIVAVP 421

  Fly   380 GYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFS 444
            .....:..|..:||:..|..|:.:.....|..:|:|.:....|:...|:.:.::..:....:|::
Mouse   422 ARLCCIILLEYFGRKWALNLTLFLVTSMCLFLLFLPQEPKSTIILTLMLAEFSMAGTLSIFFIYT 486

  Fly   445 AEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNK 509
            ||..|||:|:.|||..|:....|.|.:  :.:..:....||:..|....:.|...|.|:|||.::
Mouse   487 AELLPTVLRSTGLGMVSLAWVAGAISS--VAIFKQTKTQLPIFFCCLCCVLALCFSSLVPETGSQ 549

  Fly   510 PMPETIEDGENFGKKP------APQETAEE 533
            .:.::||.......:|      .|...|||
Mouse   550 SLRDSIEYNIRDSIEPKDRNKDVPMVIAEE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	143/515 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	98/355 (28%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	143/514 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850