DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	172/596 - (28%)
Similarity:	275/596 - (46%)	Gaps:	85/596 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELS--- 62
            |.:.:::..:|..|.:|......|..|.:......:...|..|.|..||.:|..:.|..:.|
  Rat     1 MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPG 65

  Fly    63 -------------------PH--------LWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETK 100
                               ||        .|.|........::.|.|                |:
  Rat    66 DFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDAD----------------TE 114

  Fly   101 TC-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFAS 164
            .| ..:|||.|.:.::.||.|:|||....|...:.|:|:.|:|:|:.:.|..||:.||:.....|
  Rat   115 PCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWS 179

  Fly   165 LVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVF-----LVAYVIALEMVG------------- 211
            .:|..:.|.:||:.|.:..|.:.|.:|.:..:||.     |..:.:.|...|
  Rat   180 YLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSLLL 244

  Fly   212 -----SSYRLFAGVAMQ----MFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPES 267
                 :|.:  ||..|.    :.||.|.:||...||.:..||.||:|::.|..||..|.|.:|||
  Rat   245 AVMEWTSAQ--AGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPES 307

  Fly   268 ARWLLMKGRKDEAFVIIEKAAKEN--KVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLR 330
            ||||:..||.|::...:::.|..|  |.|.     :.|..||.....|:|...:|..|.:..||.
  Rat   308 ARWLITVGRLDQSLRELQRVAAVNRRKAEA-----DTLTVEVLRSAMQEEPNGNQAGARLGTLLH 367

  Fly   331 YPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRS 395
            .|.||.:|.:....||.....:|||:.:...||.|..:...:.|.|::|.....|..|:|.|||.
  Rat   368 TPGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRL 432

  Fly   396 ILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGAS 460
            ....::::.|:.:||.|.||.:|..|..:.|::|..::.:::..:.|||:|.||||:|...:|..
  Rat   433 CQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLG 497

  Fly   461 SMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKP 525
            .:.||.|.:|.|.::|||.....|||::.|.:.:.:||.:||||||.|.|:|:||:|.:....|.
  Rat   498 QVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKK 562

  Fly   526 APQETAEEGGT 536
            ...:.|  ||:
  Rat   563 VTHDIA--GGS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	164/562 (29%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	120/384 (31%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	140/454 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950