DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Balat

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	199/552 - (36%)
Similarity:	314/552 - (56%)	Gaps:	46/552 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLP-AIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPH 64
            |.:|:|:..:|.||.|||.|...:.|| |:.||||..:.:|:.|.|...|.:|       ||.|
  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVP-------ELEP- 57

  Fly    65 LW---------NLSYPENE-----RCSYYDVDYTE--EYLNGSIP---------------RSSNE 98
             |         |||.|.|.     .||.|..:||:  .||....|               ..:.:
  Fly    58 -WTQDYVQLVKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQ 121

  Fly    99 TKTCS-SYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFF 162
            ...|. .:.||:|.|.::.|.||||||.||.|...:..:|.:|.|||:.:||.:.|..||:|:|:
  Fly   122 VVPCQHGWHYDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFY 186

  Fly   163 ASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFS 227
            |.|:|::|....:|.|..|:::...|.:||.|...:....||:|:|:||...|:|..:...:.:|
  Fly   187 AYLLLEIIACAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYS 251

  Fly   228 VGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292
            :|.::.||..|.:.|||.|.:|:::|.|:....::::|||.|||:..|:...|..|::..|:.|.
  Fly   252 LGLVVLAGVIYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNG 316

  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSW 357
            |.|..:..|:|..::...:..:..::......:.||.|.||:|||||:|...||.|:.||.|||:
  Fly   317 VRVNRDFVERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGLSY 381

  Fly   358 NTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLI 422
            ....|||:::.||.::||||:|.|.||...|:.:|||.||..:|:|.|::.:||...| |:. |:
  Fly   382 YAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYP-DIT-LL 444

  Fly   423 VACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLI 487
            :.|  :||:.|:||:..:.:.::|.:|||||.:|:..||:::.||.|:.|.:..:|:....||||
  Fly   445 LYC--VGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLPLI 507

  Fly   488 ICGALSLTAGLLSLLLPETLNKPMPETIEDGE 519
            :.|||.:..|..|||||||.|:.:|:|:|:||
  Fly   508 VMGALLILGGFASLLLPETRNRNLPQTLEEGE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	192/535 (36%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	128/355 (36%)
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	149/399 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458419
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8406
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	10	9.920