DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a13

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	187/560 - (33%)
Similarity:	303/560 - (54%)	Gaps:	48/560 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWN 67
            :..|:..:|:||.:|.|:..|:.:|..:.||...:.||::......|::.:       :..|.:|
  Rat     4 FAQVMAEVGDFGRFQVRLTILMGIPNFLSAFFVFSQVFMVLDEAHYCSVSW-------VKNHTFN 61

  Fly    68 LSYPEN-------------ERCSYYDVDYTEEYLNGSIPRSSNETKTCSS---YVYDRSKYLNSA 116
            ||..|.             |.|..:........|...:....|||:.|.|   |..:|...|.:
  Rat    62 LSAAEQLAVSIPNDTAGRPESCLMFRPPPDNASLEDILSHRFNETQACDSGWDYPENRPPSLKN- 125

  Fly   117 VTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEY 181
              |::|||.|..|..||.|:||.|:|:|:|:||.:.|.:||:|    ||::||:...:|::|..:
  Rat   126 --EFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRP----SLLMQLLLSGIASMATAF 184

  Fly   182 FS----YTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHD 242
            .|    |...|..:....:|..|.:.|:..|.||:|.|..|.|..|..|::|.|..||.||.:.:
  Rat   185 VSSFELYMTLRFALATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFALGLMALAGLAYGVRN 249

  Fly   243 WRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEV 307
            ||.|||..|.|..|.:.|:|::|||.||||.:||.:||..:::|||..|...:.:|:..|||.|
  Rat   250 WRLLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLNQLVPE- 313

  Fly   308 AEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMI 372
                      .:.|:....||.|:|.||:.||::...|||:|.:||||.:...:.|.:..:..:|
  Rat   314 ----------KTGPSGNALDLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVI 368

  Fly   373 SGAVEIPGYTLLLFTLNRWGRR-SILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSS 436
            .|.||:|.....:..:.:.||: |.|| |:.:||:..:..||:|.|:..:..|.|::||.|.:::
  Rat   369 FGVVEVPARLSSIPMMEKLGRKWSQLC-TLTLAGVMCVIIIFIPGDLPTVATALAVVGKFASSAA 432

  Fly   437 YGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSL 501
            :...|:::||..||::|..|:|..|:.:|||||:.|.:.||.:..:.:|::|.|:|.:.||||..
  Rat   433 FTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCA 497

  Fly   502 LLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQELSG 541
            |||||..:.:.:|::|.|. |:.|...:||.:....|.||
  Rat   498 LLPETRGQTLKDTLQDLEQ-GQPPRSYKTAPQRKDVEASG 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	176/523 (34%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/360 (36%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	176/523 (34%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	138/376 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm9087
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950