DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a4

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	563	Identity:	196/563 - (34%)
Similarity:	296/563 - (52%)	Gaps:	54/563 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWN 67
            ||:||..|||:||:|:.|::||....|...|:.::.|||...|:.||.:|    ....||....|
Mouse     4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVP----DTVNLSSSWRN 64

  Fly    68 LSYPEN--------ERCSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .|.|..        :.|..|                 |||.  |.|         |.::| ..:.
Mouse    65 HSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDL--EQL---------EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIF 171
            ||:..:|::.||||||||.....:..:.|||.:|||.||.:.||:||:.|||...||::.:|..|
Mouse   119 YDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGF 183

  Fly   172 GVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAG 235
            ..:...:..:..:|:...|||......::||:::..|::..|.| :|:.:.:..||::|:|:...
Mouse   184 SFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPL 248

  Fly   236 FAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIY 300
            |||||.|||.|.:|:|||||..:..:|.||||.|||:.:.|..||..||:||||.|.:..|..|:
Mouse   249 FAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIF 313

  Fly   301 EQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGN 365
            :.|       :.|:..:..|....:.||.|..|:...|::....|.:.|..|:.||.|..||.|:
Mouse   314 DPL-------ELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGD 371

  Fly   366 QLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGK 430
            ..:|..:||.:|:|.|......|....||.|:.|.:...|..||....||.|.|::.:...|:||
Mouse   372 VYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGK 436

  Fly   431 LAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLT 495
            ..|||::..:|:|:||.:||:|||:.:|.:||.:|||.|:|||...||...|.||.|:.|:|::.
Mouse   437 FGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVL 501

  Fly   496 AGLLSLLLPETLNKPMPETIED-----GENFGKKPAPQETAEE 533
            .|:::|..||:....:||.:|.     |...|||.......||
Mouse   502 IGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	183/529 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	134/356 (38%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	182/528 (34%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	147/393 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843607
Domainoid	1	1.000	282	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2273
Isobase	1	0.950	-	0	Normalized mean entropy	S3558
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.770