DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a17

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_803156.2	Gene:	Slc22a17 / 305886	RGDID:	631405	Length:	520	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	147/516 - (28%)
Similarity:	234/516 - (45%)	Gaps:	44/516 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VFLLAKPDFRC---ALPYENGSIYELSPHLWNLSYPE---NERCSYYDVDYTEEYLNGSIPRSSN 97
            :|.|| |...|   ||| .|.|.:|..|:...:|...   ....:...|..|:...:|..|...|
  Rat     6 IFTLA-PPLHCHYGALP-PNASGWEQPPNSSGVSVAGAALAASAASRVVTSTDPSCSGFAPPDFN 68

  Fly    98 ETKTC-SSYVYDRSKYL-NSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPT 160
            .   | ..:.|:....| .:|:.:|:|||...........||:||...|.|..|..:|:.||:..
  Rat    69 H---CLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGI 130

  Fly   161 FFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMF 225
            ...:|.|....||..|.|.........|.::|...:||.|..|::.||:...:.||...:|.::.
  Rat   131 VLLTLGLVGPCGVGGAAAGSSTGIMTLRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELV 195

  Fly   226 FSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYW--IIPESARWLLMKGRKDEAFVIIEKAA 288
            ...|..|..|.|....|||:||..||.|.:|||.|.|  :..||||||::|.:.:||..::...|
  Rat   196 GVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILA 260

  Fly   289 KENKVEVPNEIYEQLVDEVAEKKKQD-EMAASQPAATVF---DLLRYPNLRRKTLLIFFDWFVNS 349
            :.|:.      :.|::.|.|::..|: |.....|..:.|   .||.|.|:.:..|::.|..|:..
  Rat   261 ERNRP------HGQMLGEEAQEALQELENTCPLPTTSTFSFASLLNYRNIWKNLLILGFTNFIAH 319

  Fly   350 GVYYGLSWNTNNLGGN----QLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLA 410
            .:.:  .:.....||:    .|.:.:.||...: ....|..|::|:|||.||..:|.:.||:.|.
  Rat   320 AIRH--CYQPVGGGGSPSDFYLCSLLASGTAAL-ACVFLGVTVDRFGRRGILLLSMTLTGIASLV 381

  Fly   411 TIFVPSDMN-WLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYL 474
            .:.:...:| ..|...:::|..:..:|.....:.:||..||.||..|||....:..:||:..|..
  Rat   382 LLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQ 446

  Fly   475 KL---LGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGE-----NFGKKPAP 527
            :|   .|...:.:.|..|..|.:   |..:|||||..|.:||.:.|||     :..::|.|
  Rat   447 RLHMGHGAFLQHVVLAACALLCI---LSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	141/496 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	106/369 (29%)
Slc22a17	NP_803156.2	MFS	106..476	CDD:119392	109/381 (29%)
Slc22a17	NP_803156.2	2A0114	111..475	CDD:273326	104/375 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940