DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	197/560 - (35%)
Similarity:	293/560 - (52%)	Gaps:	60/560 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDF-------------RCA-LPY 53
            :|..:...||||.:|:|::.||||..:..||..:..|||.::||:             ||| .|.
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    54 ENGSIYELSPHLWNLSYPE----NER-----CSYY---DVDYTEEYLN----GSIPRSSNETKTC 102
            |.          |||:.||    .||     |..|   |.:.:.| |:    .:.|..|.....|
  Rat    69 EE----------WNLTTPELHVPAERRGQGHCHRYLLEDTNTSSE-LSCDPLAAFPNRSAPLVPC 122

  Fly   103 SS---YVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFAS 164
            |.   ||...|    :.|::::|||..:.:...:.::..||.|.|:...|..:|:.||...:..|
  Rat   123 SGDWRYVETHS----TIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLIS 183

  Fly   165 LVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVG 229
            .....|.||:.|.||.:..:.|.|.:.|....|.::..:||..|:|||..|...|:.:||||::|
  Rat   184 CFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLG 248

  Fly   230 FMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVE 294
            .::..|.|||...|:.:|:||:||..|||.|||::|||.|||:.:.:.::|..|:.:.||.|.
  Rat   249 IIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNG-- 311

  Fly   295 VPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNT 359
                  :.|....:|....|| ..|.|:.  .||:|.|.:|:.||::.|.||.::.||.||....
  Rat   312 ------KHLSSNYSEITVTDE-EVSNPSC--LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRL 367

  Fly   360 NNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVA 424
            ..:|||..::|.|||.||:||..|:|.|:.|.|||.....:.:|||:|.|.|.|:|..:.||...
  Rat   368 GLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTT 432

  Fly   425 CAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLII 488
            .|.:|:|.||.::..:|:.::|.:||.:||.|:...|.:...|||:||:|.. |..||..|||||
  Rat   433 VATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLII 497

  Fly   489 CGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQ 528
            .|.|:...|.|.:|||||....:|||:||.|..|.....|
  Rat   498 FGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	189/536 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	134/356 (38%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	189/536 (35%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	139/378 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347135
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900