DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a2

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	195/563 - (34%)
Similarity:	306/563 - (54%)	Gaps:	59/563 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAG---------VFLLAKPDFRCALPYENGSIY 59
            ||::.|:|||..:||:.::||.|         |:|         |||...||..|..|    ...
  Rat     5 DDILEHIGEFHLFQKQTFFLLAL---------LSGAFTPIYVGIVFLGFTPDHHCWSP----GAA 56

  Fly    60 ELSPHL-WN----LSY------PENE-----RCSYYDVDYTEEYLNGSIPRSS-----NETK--T 101
            :||... |:    |:|      |.:|     :|..|:||:.:..|:...|.||     |:..  .
  Rat    57 KLSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGP 121

  Fly   102 CS-SYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASL 165
            |. .:||:...  :|.|||:||||:.|.:.....|:..:|..:|:::.|.::|:.|||.....::
  Rat   122 CEHGWVYNTPG--SSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTI 184

  Fly   166 VLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGF 230
            ::..|.|.|.|::|.|....:.|.:.|..:...:|:.|::..|.||..||...|:..|:.|:||.
  Rat   185 LINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGL 249

  Fly   231 MLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEV 295
            ::.||.||.|.:|||||.|:|||...||.|:|.||||.|||:.:.:..:|..||:..||:|...|
  Rat   250 LILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSV 314

  Fly   296 PNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTN 360
            |..:.....||.|.||.:         .::.||:|.|.:|:.||::.::||.:|.:|.||..:..
  Rat   315 PVSLQNLTPDEDAGKKLK---------PSILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMG 370

  Fly   361 NLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVAC 425
            ..|.|..::|..|..||.|...:::.|::|.|||.....:.||||.:.||::|:|.|:.||.:..
  Rat   371 LAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITI 435

  Fly   426 AMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIIC 489
            |.:|::.||.:|..:.:.:||.:||.:||:|:...|.:..:|||:.|:|.. |.:||...||::.
  Rat   436 ACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVF 500

  Fly   490 GALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAE 532
            ..:.|.||.|.||||||..|.:||||||.||. ::|..:|..|
  Rat   501 AVVGLVAGALVLLLPETKGKALPETIEDAENM-QRPRKKERKE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	182/536 (34%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	125/356 (35%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	182/536 (34%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	132/377 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347069
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900