DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and SPAPB1E7.08c

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_594134.1	Gene:	SPAPB1E7.08c / 2543660	PomBaseID:	SPAPB1E7.08c	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	562	Identity:	120/562 - (21%)
Similarity:	229/562 - (40%)	Gaps:	139/562 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LSPHLWNLSYPENERCSYYDVDYTE-----EYLNGSIPRSSNETKTCSSYVYD-----RSKYLNS 115
            :.|.|:::|..|:::  ..||..||     |..:.:|..|.::.....|..:.     :|:.|::
pombe     5 IPPRLYDMSPTESKK--QEDVSETELVYPVELADATIQPSKSDDDLFDSNDFSKTYLAKSRILSN 67

  Fly   116 AVTE-------WNL---------------VCSRSLL-----------SATSDSLFM-----LGVL 142
            |:.|       |.|               ||:..:|           .|...:.::     ||:|
pombe    68 AMNEIGFGRYQWYLFFVAGFGWMSDNIWPVCTSLILMRLDEVDGPHPPAEGRAPYLTLSQNLGLL 132

  Fly   143 LGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIAL 207
            :|::::...:|.:||:..|..:.:...:|.|:|..:|.:.|..:...:......|...|...|.|
pombe   133 VGAMVWSLSADTIGRRWAFNLTFLFTGVFAVIAGASPNFASICVFDALWSFGVGGNLPVDSAIFL 197

  Fly   208 EMVGSSYRLFAGVAMQMFFSVGFML-------------------------TAGFAYFIHDWRWLQ 247
            |.:.||::....| |..::::|.::                         ..|:.||:
pombe   198 EALPSSHQWLLTV-MSFWWAIGQVIANLVSWGLISNFSCPDDESVCHRADNKGWRYFL------- 254

  Fly   248 IAITLPG---LLFLCYYWI-IPESARWLLMKGRKDEAFVIIEKAAKEN------KVEVPNEIY-- 300
              .|:.|   |:|...:.: :.||.::.|.||...:|...|.|.|:.|      .||   |:|
pombe   255 --FTMGGMTLLMFAARFLVSVYESPKFYLAKGDDYKAVETIHKIARINGKTCTLTVE---ELYAI 314

  Fly   301 ---EQLVDEVAEKKKQDEMAASQPAAT-VFDLLR---YPNLRR---------KTLLIFFDWFV-- 347
               ||...::.:.|..|..:.:|.... :.:.||   :.::|:         .::|:...|.|
pombe   315 DRQEQEESDLDDSKSSDAKSVTQGTTNLIVEKLRKYNFEHIRQCFGSRKLAISSILVILSWAVIG 379

  Fly   348 ------NSGVYYGLSWNTNNLGGNQLV-------NFMISGAVEIPGYTLLLFTL--NRWGRRSIL 397
                  |:.:.|.|....|   .|:.:       |.:|..|:.:|| :|:...|  .|.||:..|
pombe   380 LAFPLYNAFLPYYLETRGN---ANEPLSVAKTYRNSLIVSAIGVPG-SLIAGVLVEFRIGRKGTL 440

  Fly   398 CGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSM 462
            |.::::.|:.|.|:....:...:|...|..  .......||.:|.::.|.||:.||...:|.::.
pombe   441 CLSLILTGVFLFASTTAKTSNAYLGWNCTF--SFFSDIMYGVLYAYTPEVFPSKVRGTAVGLAAS 503

  Fly   463 VARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLP 504
            ..|:.||.:|.:.:...:....|:.:.|||.:.||:|.:..|
pombe   504 ANRILGIFSPVIAMRANLTTSAPIFVSGALFIFAGILVVFFP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	120/562 (21%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	91/430 (21%)
SPAPB1E7.08c	NP_594134.1	2A0109	68..552	CDD:129965	106/497 (21%)
SPAPB1E7.08c	NP_594134.1	MFS	122..545	CDD:119392	97/441 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2349
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.990