DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	199/546 - (36%)
Similarity:	301/546 - (55%)	Gaps:	40/546 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL-WN 67
            |||:..:||||.:||:.:.||||.:...|...:..|||...|...|    :|..:.|||... |:
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYC----QNPGVAELSQRCGWS 65

  Fly    68 ----LSY------PENE-----RCSYYDVDYTEEYLNGSIPRSS---NETK----TCS-SYVYDR 109
                |:|      |.:|     :|..|:||:.:..|:...|.||   |.::    .|. .:|||.
  Rat    66 QAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDT 130

  Fly   110 SKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVL 174
            ..  :|.|||:||||..:.......|...||..||||:.|.::|:.|||.....:.::..:.|||
  Rat   131 PG--SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVL 193

  Fly   175 AAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYF 239
            .||||:|.|..:.|::.|..:.|.::..|.:..|.|||.||....:..||.|:||.:..||.||.
  Rat   194 TAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYA 258

  Fly   240 IHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLV 304
            |.||||||:|::||..|||.|||.:|||.||||.:.|...|..|:|:.|::|....|.::....:
  Rat   259 IPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCL 323

  Fly   305 DEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVN 369
            :|.|.:|:....|         ||.|.||||:.|:::.:.||..:.:|.||..:....|.|..::
  Rat   324 EEDASEKRSPSFA---------DLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLD 379

  Fly   370 FMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAIT 434
            |..|..||.|...::|.|::|.||...:..:.:|.|.:.|..||:|.:::||.|..|.:|::..|
  Rat   380 FFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGAT 444

  Fly   435 SSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIICGALSLTAGL 498
            .....:.:.:||.:||.:||:|:...|.:..:|||..|::.. |.|:|:.||||:.|.|.||||.
  Rat   445 IVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGA 509

  Fly   499 LSLLLPETLNKPMPETIEDGENFGKK 524
            ::||||||....:|||||:.||.|::
  Rat   510 MTLLLPETKGVALPETIEEAENLGRR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	189/527 (36%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	130/356 (37%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	189/527 (36%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	149/400 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347087
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900