DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a15

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001034460.2	Gene:	Slc22a15 / 242126	MGIID:	3607704	Length:	544	Species:	Mus musculus

Alignment Length:	544	Identity:	181/544 - (33%)
Similarity:	280/544 - (51%)	Gaps:	52/544 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |..::....:||.|.||   .||..|.|::...:......|:|   ...|.|..:..:.:|.|:.
Mouse     1 MEVEEAFQAVGEMGLYQ---MYLCFLLAVLLQLYVATEAILIA---LIGATPAYHWDMADLLPNQ 59

  Fly    66 WNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLS 130
            .:.:....:..::.|...|   .|||         ....:|:..:.: .|..:||.|:.:||...
Mouse    60 SHSNQTLGKGQAFGDWLLT---ANGS---------EIHKHVHFSNSF-TSIASEWFLIANRSYKV 111

  Fly   131 ATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATT 195
            :.:.|.|..||.:|.:.|||:||:.||:..:.....|.::|.|....:|.|..:.::|.:||...
Mouse   112 SAASSSFFSGVFVGVISFGQLSDRFGRRKVYLTGFALDILFAVANGFSPSYEFFAVTRFLVGMMN 176

  Fly   196 SGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCY 260
            .|:.|||:|:..|.||::|...||....:||:||....|...|||..||.|.:.:.|.|.|....
Mouse   177 GGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAVLVNLQGTLVFLL 241

  Fly   261 YWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPA--- 322
            ...||||.|||..:||..||...:...||.|                  :|.:...:.:.||
Mouse   242 SLFIPESPRWLYSQGRLSEAEEALYFIAKRN------------------RKLKCTFSLTHPANRS 288

  Fly   323 ----ATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTL 383
                .:..||.||..|...||::.|.|||.|.|||||:.:..:|||:...|..:||.:|||.|.|
Mouse   289 YRATGSFLDLFRYRILLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPL 353

  Fly   384 LLFTLN-RW-GRRSILCGTMMVAGISLLATIFVPSDMNWLIVA------CAMIGKLAITSSYGTI 440
            .::.:| || ||:..|...:.:.|::.|..:|:|...:..:.|      .:::|||.|::::..:
Mouse   354 CIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIV 418

  Fly   441 YIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPE 505
            ||:::|.:|||:|||||||.||.:|||||:||::..|.|:...||.|:.||..||:|||||||||
Mouse   419 YIYTSELYPTVIRNVGLGACSMFSRVGGIIAPFVPSLKEVQWSLPFIVFGATGLTSGLLSLLLPE 483

  Fly   506 TLNKPMPETIEDGENFGKKPAPQE 529
            |||.|:.||..|.:.:..:...:|
Mouse   484 TLNSPLLETFSDLQMYSYRRLGEE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	176/517 (34%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	132/370 (36%)
Slc22a15	NP_001034460.2	MFS	121..469	CDD:119392	130/365 (36%)
Slc22a15	NP_001034460.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840