DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a26

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	566	Identity:	168/566 - (29%)
Similarity:	270/566 - (47%)	Gaps:	54/566 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQ--KRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY-------ENG 56
            |.:.|::..:|..|.:|  :..:.|:|  .::...|.:...|..|....||.:..       .|.
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLIC--NVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNN 63

  Fly    57 SIYELSPHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRSKYL 113
            |.......|..:|.|     ..|:| .:....:.....|||....:. :|:.| ..:|||:..:|
Mouse    64 SGILSQDDLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYDQRTFL 128

  Fly   114 NSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVA 178
            ::.||||||||....|::.:..:|::|||.|..:.|.:|||.|||..|..:|:...|.|...|:|
Mouse   129 STTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTCTALA 193

  Fly   179 PEYFSYTISRMIVG-----ATTSGVFLV---------AYVIALEMVGSSYRLFAGVAMQMFFSVG 229
            |.:|.|.:.|.:.|     ..|:.|.|:         |.|..|.|  ||:..            |
Mouse   194 PTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSM--SSHHF------------G 244

  Fly   230 FMLTAGFAYFIHDWRWLQIAITLP--GLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292
            .::.||.|:...:|..||:||::|  .||.....| :.||||||::..:..:|...:.|.|.:|.
Mouse   245 GLILAGLAFAFQNWHHLQLAISVPIFVLLIPTSRW-LTESARWLIVTNKPQKALQELRKVASKNG 308

  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSW 357
            ::...::   |..||.....:||:|..:...::.||...||||::..|:....|:......|::.
Mouse   309 IKNSEDV---LTMEVVRTIMKDEIAIPRTKPSLRDLFHMPNLRKRLCLLCLLRFLQISPTVGINM 370

  Fly   358 NTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLI 422
            |..:|.||..:...::.|..||...|..|.||..|||.......::.||.||:.:.||.:|..|:
Mouse   371 NLQHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSVPQEMQTLL 435

  Fly   423 VACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLI 487
            |....:...:....|.:..::|:|..|||:|...||...:...||..|:|.:.:|......||.|
Mouse   436 VVLITLAGGSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLPWI 500

  Fly   488 ICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEE 533
            |.|.||:..|||.|:||||.|:|:|::|:|.| .|.:.:.|:..|:
Mouse   501 IYGVLSILGGLLPLILPETKNQPLPDSIQDVE-CGWESSKQKKEED 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	160/535 (30%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	111/371 (30%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	127/414 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940