Protein Alignment Orct and SV2C

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 116/566 - (20%)
• Similarity: 200/566 - (35%)
• Gaps: 192/566 - (33%)

  Fly   113 LNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAV 177
            |.||.|:   :|..:..|....|:..||:::|:..:|.::||:|||.:....:.:...|..|::.
Human   176 LPSAETD---LCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSF 237

  Fly   178 APEYFSYTISRMI----VGATTSGVF-LVAYVIALE-------------MVGSSYRLFAGVAMQM 224
            ...|..:...|::    :|.....|| ..|.|:|.|             |:|..|.  :.:|..:
Human   238 VQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYA--SAMAWAI 300

  Fly   225 FFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVII----- 284
            ....|:..:.|.||..|.||...|...||.:..:.....:|||.|:||..|:.|||::|:
Human   301 IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHD 365

  Fly   285 ---------EKAAKENKVEVPNEIYEQLVDEVAEKKK-------------QDEMAASQPAATVFD 327
                     ||....||::.|.:|     ||:.|.:.             :.|:....  .|...
Human   366 TNMRARGQPEKVFTVNKIKTPKQI-----DELIEIESDTGTWYRRCFVRIRTELYGIW--LTFMR 423

  Fly   328 LLRYPNLRRKTLLIFFDWFVNSGVYYGLS-W---------------NTNNLGGNQLVNFMISGAV 376
            ...|| :|..|:.:...||..|..||||| |               .|.|:..::..||.|:..:
Human   424 CFNYP-VRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTM 487

  Fly   377 E---------------------------------------------------------------- 377
            |
Human   488 ENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKF 552

  Fly   378 -----------------------------------------IPGYTLLLFTLNRWGRRSILCGTM 401
                                                     :||..:....::|.||.::|.|:|
Human   553 IDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSM 617

  Fly   402 MVAGISLLATIFVPSDMNWLIVACAMIGKLAI-----TSSYGTIYIFSAEQFPTVVRNVGLGASS 461
            :::|||.....|..|:       ..|||.|.:     .|::.::.:.:.|.:||..|..|.|..:
Human   618 VLSGISCFFLWFGTSE-------SMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLN 675

  Fly   462 MVARVGGILAPYL-KLLGEIWRPLPLIICGALSLTAGLLSLLLPET 506
            .:.:...:|...: ..|..|.:.:|:::...:.:..||:.|.||:|
Human   676 ALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDT 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	116/566 (20%)
		MFS	135..491	CDD:119392	104/527 (20%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	116/566 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	113/562 (20%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		0/43 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940