DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a19

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	553	Identity:	174/553 - (31%)
Similarity:	278/553 - (50%)	Gaps:	30/553 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQ--KRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY-------ENG 56
            |.:.|:|..:|..|.:|  ..|:.|:|  ..:.|.|.|...|..|.|..||.:|.       :||
Mouse     1 MAFQDLIIQIGSLGRFQILHMIFVLIC--HALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNG 63

  Fly    57 SIYELSPHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKYL 113
            |.......|..:|.|     ..::| .|....:...:|||:.|. :..:|:.| ..:|||:|.:|
Mouse    64 SRILSQDDLLRISIPLDSNLRPDKCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVDGWVYDQSTFL 128

  Fly   114 NSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVA 178
            ::.||:|:|||....|::.:..::|.|:.:|.::.|.:|||.|||..|..||:...|.....|.|
Mouse   129 STTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMAITETCVAFA 193

  Fly   179 PEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFF---SVGFMLTAGFAYFI 240
            |.:..|...|.:.|..:|.:...:.::.||.....   |..:.|.:.|   .||..|..|.|:..
Mouse   194 PSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPK---FQALVMALIFIASGVGQTLLGGLAFAF 255

  Fly   241 HDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVD 305
            .:|..||:|:::|..|.|.....:.||||||:|..:..::...::|||..|:::...   :.|..
Mouse   256 RNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNRIKNSG---DALTL 317

  Fly   306 EVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNF 370
            ||.:...::|:.|:|...:..||.|.||||::..|:.|..||:.....||..|...|..|..:..
Mouse   318 EVVKTIMKEELEAAQTKPSPLDLFRTPNLRKRICLLSFVRFVSVMSLLGLLINIQYLSNNVFLLQ 382

  Fly   371 MISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITS 435
            .:.|.|.||...|..|::|..|||......|.|.|||:||.:|:|.:|..|.|..:.:|....::
Mouse   383 CLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILRVFLSTLGGAISSA 447

  Fly   436 SYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLS 500
            |..:..:.:.|..||::|...||...:....||.|:|.|.:|......||.||.|.|....||::
Mouse   448 SITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILPFLGGLVA 512

  Fly   501 LLLPETLNKPMPETIEDGENFGKKPAPQETAEE 533
            ||||||.|:|:|::|:|.||  |:.:.:|..::
Mouse   513 LLLPETKNQPLPDSIQDIEN--KRKSSKEAKKD 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	165/522 (32%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	111/358 (31%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	164/521 (31%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940