DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	559	Identity:	197/559 - (35%)
Similarity:	292/559 - (52%)	Gaps:	58/559 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDF-------------RCA-LPY 53
            :|..:...||||.:|:|::.||||..:..||..:..|||.::||:             ||| .|.
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    54 ENGSIYELSPHLWNLSYPE----NER-----CSYYDVDYTEEYLNGS------IPRSSNETKTCS 103
            |.          |||:.||    .||     |..|.::.|......|      .|..|....:||
Mouse    69 EE----------WNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCS 123

  Fly   104 S---YVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASL 165
            .   ||...|    :.|::::||||.:.:...:.::..||.|.|:...|..:|:.||...:..|.
Mouse   124 GDWRYVETHS----TIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISC 184

  Fly   166 VLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGF 230
            ....|.||:.|.||.:..:.|.|.:.|....|.::..:||..|:|||..|...|:.:||||::|.
Mouse   185 FGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGI 249

  Fly   231 MLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEV 295
            ::..|.|||...|:.:|:||:||..|||.|||::|||.|||:.:.:.::|..|:.:.||.|.
Mouse   250 IILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNG--- 311

  Fly   296 PNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTN 360
                 :.|....:|....|| ..|.|:.  .||:|.|.:|:.||::.|.||.::.||.||.....
Mouse   312 -----KHLSSNYSEITVTDE-EVSNPSC--LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLG 368

  Fly   361 NLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVAC 425
            .:|||..::|.|||.||:||..|:|.|:.|.|||.....:.:|||:|.|.|.|:|..:.||....
Mouse   369 LIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTV 433

  Fly   426 AMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIIC 489
            |.:|:|.||.::..:|:.::|.:||.:||.|:...|.:...|||:||:|.. |..||..|||||.
Mouse   434 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIF 498

  Fly   490 GALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQ 528
            |.|:...|.|.:|||||....:|||:||.|..|.....|
Mouse   499 GILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	189/535 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	134/356 (38%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	189/535 (35%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	139/378 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843681
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8821
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850