DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	549	Identity:	197/549 - (35%)
Similarity:	300/549 - (54%)	Gaps:	46/549 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL-WN 67
            |||:.|:||||.:||:.:.||||.:...|...:..|||...||..|..|    .:.|||... |:
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSP----GVAELSQRCGWS 65

  Fly    68 LSYPENE------------------RCSYYDVDYTEEYLNGSIPRSS---NET----KTCS-SYV 106
               |..|                  :|..|:||:.:..|:...|.||   |.:    ..|. .:|
Mouse    66 ---PAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWV 127

  Fly   107 YDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIF 171
            ||...  :|.|||:||||..:.......|...||..||||:.|.::|:.|||.....:.::..:.
Mouse   128 YDTPG--SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLS 190

  Fly   172 GVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGF 236
            |||.||||:|.|..:.|::.|..:.|.::..|.:..|.|||.||....:..|:.|:||.:..||.
Mouse   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGV 255

  Fly   237 AYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYE 301
            ||.|.||||||:|::||..|||.|||.:|||.||||.:.|..:|..|:|:.|::|:...|.::..
Mouse   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKM 320

  Fly   302 QLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQ 366
            ..::|.|.:::....|         ||.|.|:||:.||::.:.||..:.:|.||..:....|.|.
Mouse   321 MCLEEDASERRSPSFA---------DLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANL 376

  Fly   367 LVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKL 431
            .::|..|..||.|...::|.|::|.||...:..:.:|||.:.|..||:|.:::||.|..|.:|::
Mouse   377 YLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRM 441

  Fly   432 AITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIICGALSLT 495
            ..|.....:.:.:||.:||.:||:|:...|.:..:|||..|::.. |.|:|:.||||:.|.|.|:
Mouse   442 GATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLS 506

  Fly   496 AGLLSLLLPETLNKPMPETIEDGENFGKK 524
            ||.::||||||....:|||||:.||.|::
Mouse   507 AGAVTLLLPETKGVALPETIEEAENLGRR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	186/530 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/356 (36%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	186/530 (35%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	147/400 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8821
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850