Protein Alignment Orct and Slc22a1

DIOPT Version :10

• Sequence 1: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 549
• Identity: 197/549 - (35%)
• Similarity: 300/549 - (54%)
• Gaps: 46/549 - (8%)

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL-WN 67
            |||:.|:||||.:||:.:.||||.:...|...:..|||...||..|..|    .:.|||... |:
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSP----GVAELSQRCGWS 65

  Fly    68 LSYPENE------------------RCSYYDVDYTEEYLNGSIPRSS---NET----KTCS-SYV 106
               |..|                  :|..|:||:.:..|:...|.||   |.:    ..|. .:|
Mouse    66 ---PAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWV 127

  Fly   107 YDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIF 171
            ||...  :|.|||:||||..:.......|...||..||||:.|.::|:.|||.....:.::..:.
Mouse   128 YDTPG--SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLS 190

  Fly   172 GVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGF 236
            |||.||||:|.|..:.|::.|..:.|.::..|.:..|.|||.||....:..|:.|:||.:..||.
Mouse   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGV 255

  Fly   237 AYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYE 301
            ||.|.||||||:|::||..|||.|||.:|||.||||.:.|..:|..|:|:.|::|:...|.::..
Mouse   256 AYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADLKM 320

  Fly   302 QLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQ 366
            ..::|.|.:::....|         ||.|.|:||:.||::.:.||..:.:|.||..:....|.|.
Mouse   321 MCLEEDASERRSPSFA---------DLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANL 376

  Fly   367 LVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKL 431
            .::|..|..||.|...::|.|::|.||...:..:.:|||.:.|..||:|.:::||.|..|.:|::
Mouse   377 YLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRM 441

  Fly   432 AITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIICGALSLT 495
            ..|.....:.:.:||.:||.:||:|:...|.:..:|||..|::.. |.|:|:.||||:.|.|.|:
Mouse   442 GATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLS 506

  Fly   496 AGLLSLLLPETLNKPMPETIEDGENFGKK 524
            ||.::||||||....:|||||:.||.|::
Mouse   507 AGAVTLLLPETKGVALPETIEEAENLGRR 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_524479.1	2A0119	11..514	CDD:273328	186/530 (35%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	186/530 (35%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)