DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	546	Identity:	173/546 - (31%)
Similarity:	290/546 - (53%)	Gaps:	23/546 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |.:.:::..:|..||:|.....||.||.:..|.|.|..:|....||..|. |..|.|   |.|
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCR-PPPNAS---LEP-- 59

  Fly    66 WNLSYPEN---ERCSYYDVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKYLNSAVTEWNLVCS 125
            |.|....|   |:|..:     ....|.|:|. :...|:.| ..::|:.::  ::.||||:|||.
Mouse    60 WVLPLGPNGKPEKCLRF-----VHLPNASLPNDTQGATEPCLDGWIYNSTR--DTIVTEWDLVCG 117

  Fly   126 RSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMI 190
            .:.|...:.|:||.|:|:|..:||::||:.||||....|.:|....|..||.:|....|.|.|.:
Mouse   118 SNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFL 182

  Fly   191 VGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGL 255
            .|.:.||:.|...::.:|.|.:|.|..:...:...:::|..:..|.||.:..|||||::::....
Mouse   183 CGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFF 247

  Fly   256 LFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQ 320
            :|....|.:|||.|||::.|:..:|...:::.|..|.   ..|..|:|..|..:...|.::.:::
Mouse   248 IFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNG---KKEEGEKLTVEELKFNLQKDITSAK 309

  Fly   321 PAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLL 385
            ....:.||.|...|||.|..:...||.....||.|:......|.|..:..:|.|.|:||...:.:
Mouse   310 VKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITI 374

  Fly   386 FTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPT 450
            .:::..|||......:::||:::||.|||.|:|..|..|.|:.||..::.|:..::::::|.:||
Mouse   375 LSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPT 439

  Fly   451 VVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETI 515
            |:|..|:|.|::.||||.::||.:|:.||:...:|.:|.|.::|..|..:..|.||||:|:||||
Mouse   440 VLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETI 504

  Fly   516 EDGENFGK--KPAPQETAEEGGTQEL 539
            ||.:::.:  |...||...|..:|.:
Mouse   505 EDIQDWYQQTKKTKQEPEAEKASQTI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	162/507 (32%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	113/355 (32%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	162/507 (32%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980