DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a25

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	153/545 - (28%)
Similarity:	270/545 - (49%)	Gaps:	32/545 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY---------ENG 56
            |.:.|::..:|..|.:|......:.:..|:.:.|.|...|....|:.||.:|.         :||
  Rat     1 MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNG 65

  Fly    57 SIYELSPHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKYL 113
            ::.:  ..|..:|.|     ..|:| .:....:...:|||:... :..:|:.| ..:|||:|.:|
  Rat    66 NLSQ--DDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTFL 128

  Fly   114 NSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVA 178
            ::.:|||:|||....|.:.:..||:.|:|:|::::|.::|:.||:.....:.:...:....||.|
  Rat   129 STIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAFA 193

  Fly   179 PEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDW 243
            |.:..|...|.:.|.:.|.|...:.::.:|.....::..|...:....::|..:.||.|:.:.:|
  Rat   194 PTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQTVLAGLAFTVRNW 258

  Fly   244 RWLQIAITLPGLLFLCYYWIIP-----ESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQL 303
            ..|.:|:::|     .::.::|     ||||||:|..:..:....:.|.|..|.::...::   |
  Rat   259 HHLHLAMSVP-----IFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDV---L 315

  Fly   304 VDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLV 368
            ..||.....::|:.|||..::::||.|.||||::..|:....||......||..|..:|..|..:
  Rat   316 TIEVVRTIMKEELEASQTKSSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLRINVFL 380

  Fly   369 NFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAI 433
            ...:.|.:.||...:.:|.:|..|||......:.:.|||:||.||||.:|..|.:..|..|.:..
  Rat   381 LQCLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVPQEMQILRMVLATFGGVFS 445

  Fly   434 TSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGL 498
            ..|..:..:.:.|..||::|...||...:....|..|:|...:|......||.||.|.||...||
  Rat   446 FVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSFLGGL 510

  Fly   499 LSLLLPETLNKPMPETIEDGENFGK 523
            :.||||||.|:|:|::|:|.||.|:
  Rat   511 VVLLLPETKNQPLPDSIQDVENEGR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	146/524 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	97/360 (27%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	145/523 (28%)
		Aldolase_II	39..>85	CDD:294146	10/47 (21%)
		MFS	125..506	CDD:119392	108/388 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940