Protein Alignment Orct and Slc22a6

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_032792.2
• Gene: Slc22a6 / 18399
• MGIID: 892001
• Length: 545
• Species: Mus musculus
• Alignment Length: 556
• Identity: 169/556 - (30%)
• Similarity: 286/556 - (51%)
• Gaps: 25/556 - (4%)

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-----YENGSIYE 60
            |.::|::..:|..|.:|.....::..|.::.|.|.....|..|.|...|..|     .::|.:..
Mouse     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEA 65

  Fly    61 LSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNSAVTEWNLVC 124
            ..| |.....||:  |..:...:     ||:....:..|:.| ..:|||.|.:.::.||||||||
Mouse    66 WLP-LDKQGRPES--CLRFPFPH-----NGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVC 122

  Fly   125 SRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRM 189
            |.......:.||||:|||||:::||.::|:|||:.....:.:...:.|..||.||.|..|.|.|:
Mouse   123 SHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRL 187

  Fly   190 IVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPG 254
            :.|.:.:.:.:....:.:|.:....|.:.|..:...:|:|..|.||.||.:..||.||:|:::|.
Mouse   188 LSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPF 252

  Fly   255 LLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAAS 319
            .:...|.|...|||||....||.|.....:::.|:.|..:   |...:|..||.:...|.|:..:
Mouse   253 FVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQ---EEGAKLSIEVLQTSLQKELTLN 314

  Fly   320 QPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLL 384
            :..|:..:|||.|.|||..|.:...||..|..||||..:....|.:..:..:|.|||::|...:.
Mouse   315 KGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVC 379

  Fly   385 LFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFP 449
            ...:|..|||.....::::|||.:|....:|.....:..:.|::||..:.||:..|::::.|.:|
Mouse   380 FLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYP 444

  Fly   450 TVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPET 514
            |::|..|||..|.:||||.|::|.:.:..|.:..:||.|.||:.:.|..::.||||||.:|:|:|
Mouse   445 TMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDT 509

  Fly   515 IEDGENFGKKPAPQETAEEG--------GTQELSGM 542
            ::|.::..:....|:..|:.        .|||.:|:
Mouse   510 VQDLKSRSRGKQKQQQLEQQKQMIPLQVSTQEKNGL 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	159/508 (31%)
		MFS	135..491	CDD:119392	114/355 (32%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	159/508 (31%)
		MFS	129..499	CDD:119392	118/372 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..545		5/29 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.980