DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and C06H5.6

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_507509.3	Gene:	C06H5.6 / 180170	WormBaseID:	WBGene00007394	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	150/548 - (27%)
Similarity:	247/548 - (45%)	Gaps:	57/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-YENGSIYELSPHLWN 67
            |.|:|..|::|.||...|.:.....::.|.:.:...|:....:|.|.|| .|:......||.:
Worm    28 DKVLTAFGKYGRYQMLAYVITTSVHMLFALNMMIMPFITKSVEFLCDLPDPESIDSAHFSPLV-- 90

  Fly    68 LSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTC-----SSYVYDRSKYLNSAVT-EWNLVCSR 126
                 .:.|...|...             |.|..|     :||.|...|  .|.:| :::|||..
Worm    91 -----GDSCHLQDTQL-------------NITIDCLAVNGASYNYLADK--KSTITSDFDLVCEY 135

  Fly   127 SLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIV 191
            ..::..:.|:|::|.::.|....|:||.|||:|.|...|.:.:...::.|.||.|..:.:.|.|.
Worm   136 QGMAEHATSIFLVGGMIVSPFVSQLSDILGRRPLFLIPLYISVAANLICAAAPNYLIFLLFRFIS 200

  Fly   192 GATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLL 256
            |..|:...:..:|:.:|.|...:|....|...:.:..|:||...|..|..:||.|..|.::||||
Worm   201 GVATTSFSMTGFVLCMESVSLEFRSLIPVLTTISWVGGYMLAGVFYVFFKNWRVLYFAASVPGLL 265

  Fly   257 FLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQP 321
            .:.::|..|||..||:.|....:....|.::...||..:      .|:|     .:..:...:.|
Worm   266 TIPFFWFTPESLHWLMTKQNDRKIKKYINESVAFNKQTI------SLID-----CRNIQTVDNAP 319

  Fly   322 AAT---VFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTL 383
            |.|   .|..|.||.:....::..|...|.||.|:.||..:..|..::...:.:||.||:|...|
Worm   320 ATTKTRTFRALFYPKIFVHVVINSFILIVMSGTYWALSLYSTELSEDETTGYFLSGLVELPAGFL 384

  Fly   384 LLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIY----IFS 444
            .:|.|..:.|:::...::....:.:|.|:::|...|:     .||..|...|:...::    :..
Worm   385 SVFLLIAFKRKTVSFYSLAFTAVFMLCTVYIPMQGNY-----KMIFPLLAKSTNSIVWASQPLLY 444

  Fly   445 AEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNK 509
            :|..||.:|||..|..|.|..:|.|.|||:..|..|.:..|.|:...:|:.|..|.||.|||.||
Worm   445 SEATPTTIRNVFSGVVSFVGELGSIGAPYMNRLTAINQDAPAILISIMSIVAAFLVLLQPETKNK 509

  Fly   510 PMPETIED---GENF--GKKPAPQETAE 532
            .:||.::.   |..|  .||....|.:|
Worm   510 KLPEDLDQFDAGPLFRGWKKQKDLEASE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	140/516 (27%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	101/362 (28%)
C06H5.6	NP_507509.3	MFS_SLC22	115..504	CDD:340875	114/406 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030