DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and C46C2.2

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_501604.2	Gene:	C46C2.2 / 177744	WormBaseID:	WBGene00008110	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	140/560 - (25%)
Similarity:	235/560 - (41%)	Gaps:	75/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HLGEFGPYQKRIYYLLCLPAIVCAF---HKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSY 70
            |:...|.|  |:..|:.:...:|.|   .:|..:||...|...|....:....|::
Worm     2 HIIPPGIY--RVDVLILISYQMCHFFSIQQLFPIFLNYTPKTNCIQTAQGKVCYDV--------- 55

  Fly    71 PENERCSYYDVDYTEEYLNGSIPRSSNETKTCSS--YVYDRSKYLNSAVTEWNLVCSRSLLSATS 133
            |:: :|    ::|.|.:.|    ..:|.|.|..|  :......|.:||..|:.:.|.........
Worm    56 PKS-KC----LEYNENFPN----LCANLTGTALSDCHTEKSHSYYSSAAMEFEIYCRPGWKDFRP 111

  Fly   134 DSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGV 198
            ..:..:|||:|::|.|.::|::|||.||..|:::.:....|:|......::.|.|.:.|...:|.
Worm   112 AFVQYVGVLIGNIILGYVADQIGRKKTFILSMLIGIPSLSLSATFNSIAAFYIFRALTGIGIAGT 176

  Fly   199 FLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLC-YYW 262
            .:|.:....|:| |.::.|.......:.:...|||. .|.|..:||.......:..|:.|. .|:
Worm   177 MIVGWAYFSELV-SPHQRFKLRTFSNWANARIMLTL-VALFTGEWRLSSHVSAVISLITLAIVYF 239

  Fly   263 IIPESARWLLMKGRKDEAFVIIEKAAKENKVE-VPNEIYEQLVDEVAEKKKQDEMAASQPAATVF 326
            |:|||..||..|||.:||.|..::.|....:| ||....|:..|.|..:|          |..:.
Worm   240 ILPESHIWLRKKGRYEEAEVSRKRIADLAGIEFVPMPPPEKAADNVEPEK----------AVNIC 294

  Fly   327 DLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNF----MISG----AVEI----- 378
            .:...|.||:..|:::..|||.....|    .|:..||:...||    .:||    .|.|
Worm   295 TVFADPQLRKNILILWLMWFVTGMTAY----LTDLCGGDMTKNFWVGQFLSGILLSVVRIIMGFA 355

  Fly   379 PGYTLLLFTLNRWGRRSILCGTMMVAGI---SLLATIFVPSDMNWLIVACAMIGKLAITSSYGTI 440
            .||      |...|||.:|..:..:|.:   .::|.:|......|...|..:...:..:..:...
Worm   356 DGY------LPWMGRRFVLLCSQSLAIVFFGCVIAFLFAGEKGQWYYTAVYLASFVFTSIVWEPC 414

  Fly   441 YIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLS-LLLP 504
            |:.::|..||.||.....:.|:|.|...|.|..|..|..::.|...:|..:|.||..:.: ..|.
Worm   415 YLCASELMPTDVRATSTASCSIVGRFANIGASMLSGLKTVYEPGVHMISISLGLTNVVAAYFFLQ 479

  Fly   505 ETLNKPMPETIEDGENFGKKPAPQETAEEGGTQELSGMLN 544
            ||.|.    :::.......||     ||:...||:..::|
Worm   480 ETKNC----SLDKAGTSAAKP-----AEKANEQEMKDLIN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	132/526 (25%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	99/373 (27%)
C46C2.2	NP_501604.2	2A0119	58..486	CDD:273328	119/462 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850