DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and K05F1.6

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	605	Identity:	173/605 - (28%)
Similarity:	290/605 - (47%)	Gaps:	87/605 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENG----SIYELSP 63
            ::.::..:|....:|..||.|:.|..|..|...|..|:::..|:|:|.:|..|.    :|....|
Worm   202 FEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGP 266

  Fly    64 HLW------NLSYP----------ENERCSYYDVDYTEEYLNGSIPRSSNET------------K 100
            :||      |:|:.          :.:.|.:|:.. .|.|  ..:.|...||            |
Worm   267 YLWGVDDIKNISFVFPNANSDGAYQRDSCYFYERS-EERY--RQLRRMPLETAMSEAWKDVAPKK 328

  Fly   101 TCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASL 165
            .|.:|.:::...:.:.||::||||........:...:.:|.|||.::.|..|||:|||||.....
Worm   329 KCQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLGGIASDKIGRKPTIIGFG 393

  Fly   166 VLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGF 230
            :|..:.||.......|..:.:.|::.........|.||.:.:|:.|:.||...|..:|..:::|:
Worm   394 ILSSMLGVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGY 458

  Fly   231 MLTAGFAYFIHDWRWLQI---AITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292
            .|.|..||....|:.:|:   .:....::|:|   .||||.|||:::.|..||..:|.||.:|..
Worm   459 ALLALIAYLTKSWKTIQVIAAGLHFMSIIFIC---SIPESPRWLMVQNRVSEAEEVIRKACREPP 520

  Fly   293 V-----------EVPNEIYEQLV---DEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFF 343
            .           .:|:::  :||   :....||...::.       ..||.....||.:|:.:..
Worm   521 FPFNMCTTSKCGNLPSDL--ELVSHRERKLNKKNGGKIG-------FLDLFTMKELRYRTISVCI 576

  Fly   344 DWFVNSGVYYGL--SWNTNNLGGNQL------VNFMISGAVEIPGYTLLLFT---LNRWGRRSIL 397
            .:...:.|||||  :.:..:..|..|      :|..|:||:|||    .||.   :.:.||:..|
Worm   577 VFMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIP----TLFACVWMMQLGRKKAL 637

  Fly   398 CGTMMVAGISLL-ATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASS 461
            ..|::.:|:.:: |.:.:.|....|.:|....||:|:..::..:|||::|.:||||||..:|.:|
Worm   638 MLTLITSGLFIIVAMLSMVSGHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTS 702

  Fly   462 MVARVGGILAPYLKLLGEIWRPL-PLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKP 525
            ||||.|..|:.|:.||..|..|: |:||....||.||:|..:||||..||:|||::|..|| .:|
Worm   703 MVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAGMLVFVLPETSEKPLPETLDDAINF-LEP 766

  Fly   526 APQETAEEG-----GTQELS 540
            ..|.....|     |.|:::
Worm   767 TKQVNCMMGRFGVFGHQKMT 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	163/564 (29%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	114/385 (30%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	126/428 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850