DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a27

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	550	Identity:	153/550 - (27%)
Similarity:	260/550 - (47%)	Gaps:	29/550 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQ-KRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY-------ENGS 57
            |.:.:::..:|..|.:| .:|.:||.|.|||.. |.....|..|.|:.||.:|.       :|||
Mouse    26 MSFQELLNQVGSLGRFQILQIVFLLLLNAIVVP-HIAMENFTAAIPNHRCWVPILDNDTASDNGS 89

  Fly    58 IYELSPHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKYLN 114
            .......|..:|.|     ..|:| .:....:...:|||:... |..:|:.| ..:|||||.:|:
Mouse    90 RILSQDDLLRISIPLDSNLRPEKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLS 154

  Fly   115 SAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAP 179
            :.||||:|||....|::.:...||:|:.:|.:|.|.:||:||||.....:|:...|.....|.||
Mouse   155 TIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCALLQFAITETCVAFAP 219

  Fly   180 EYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWR 244
            .:|.|...|.:.|.:...:.:.::::.||.....:.......:....::|:|::||.|:....|.
Mouse   220 SFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAALLSCAPNIGYMISAGLAFLFRIWH 284

  Fly   245 WLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAE 309
            .||:.:::|...||.....:.||||||::..:..:....:.|.|..|.::...:    |..|:..
Mouse   285 HLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGD----LTMEIVR 345

  Fly   310 KKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGN-QLVNFMIS 373
            ...:.|:.|::...::.||.....||::..::.|.....:...:||:.:..:|..| .|:.|:||
Mouse   346 TSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFMRLFFTVSIFGLAVHLQHLSSNIILLQFLIS 410

  Fly   374 GAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYG 438
             |:.|....:..|.||..|||......|.:.||.:|..:|||.:|..|.:..|.:.:...:...|
Mouse   411 -ALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFILIAVFVPQEMQTLRIIMATLAEGISSLCVG 474

  Fly   439 TIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLL 503
            ...:.:.|..||.:|...:|........|..|:|...||...:..:|.|..|..|:.......||
Mouse   475 VSRLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYYANMPWIFYGGFSIFNAFTVFLL 539

  Fly   504 PETLNKPMPETIED-GENF-----GKKPAP 527
            |||.|:|:|::..| |.::     |||..|
Mouse   540 PETKNQPLPDSTHDVGNDWKESRKGKKEDP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	146/519 (28%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	91/356 (26%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	111/410 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940