Protein Alignment Orct and SLC22A9

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_543142.2
• Gene: SLC22A9 / 114571
• HGNCID: 16261
• Length: 553
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 161/559 - (28%)
• Similarity: 279/559 - (49%)
• Gaps: 27/559 - (4%)

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-YENGSIYE---- 60
            |.:.|::.|.|:...:|......|.:.|:....|.:...|....|..||.:. .:|.::.:
Human     1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTG 65

  Fly    61 -LSPH-LWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRSKYLNS 115
             ||.. |..:|.|     ..|:| .:....:...:|||:.|.:|: :.:.| ..:||||..:.::
Human    66 ALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSST 130

  Fly   116 AVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPE 180
            .||||:|||....|::.:..:||.|:::|.::.|.:||:.||:.......:...|.|..||:||.
Human   131 IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT 195

  Fly   181 YFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFA-GVAMQMFFS-VGFMLTAGFAYFIHDW 243
            :..|...|.:.|  .:.:.|:...|.|....:::|..| |:.:.|..| :.||..||.|:.|.||
Human   196 FLIYCSLRFLSG--IAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDW 258

  Fly   244 RWLQIAITLP-GLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEV 307
            ..||:.:::| .::||...|:: ||||||::..:.:|....:.|||..:.::   ...:.|..|:
Human   259 HILQLVVSVPYFVIFLTSSWLL-ESARWLIINNKPEEGLKELRKAAHRSGMK---NARDTLTLEI 319

  Fly   308 AEKKKQDEM-AASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFM 371
            .:...:.|: ||.:...::.::|..||:.::..|:.|..|.|...|:||:.:..:||.|..:...
Human   320 LKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQT 384

  Fly   372 ISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSS 436
            :.|||.:....:..:.|....||:.....|.:..|.|||.||||.:|..|....|.:|..|...:
Human   385 LFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALA 449

  Fly   437 YGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSL 501
            ....:....|..||::|...:|.::..|.:.|.|||.:.:|.....|||.||.|.....:|...|
Human   450 NTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFL 514

  Fly   502 LLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQELS 540
            |||||.|||:.:||:|.:|  ::..|:|..:|....|::
Human   515 LLPETRNKPLFDTIQDEKN--ERKDPREPKQEDPRVEVT 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	150/521 (29%)
		MFS	135..491	CDD:119392	104/359 (29%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	150/521 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..553		7/26 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940