Protein Alignment Orct and SLC22A7

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 188/615 - (30%)
• Similarity: 287/615 - (46%)
• Gaps: 96/615 - (15%)

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-----YENGSIYE 60
            ||:::::..:|.|||:|.|...||.||.::...|.|..:||.|.|..|||||     :.:..::
Human     1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVW- 64

  Fly    61 LSPHLWNLSYPENERCSYYDVDYTEEYLN---GSIPRSSNE------TKTCS-SYVYDRSKYLNS 115
            |..||  ...|:....|.....|.:...|   |...:|..|      |..|| .:.||.|::.::
Human    65 LEAHL--PREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSST 127

  Fly   116 AVT-------------------------------------------------------------E 119
            ..|                                                             |
Human   128 IATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRESLGGLLSGME 192

  Fly   120 WNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSY 184
            |:|||.:..|:..:.:.|..|||:|::.||.:||:.||:.....:.|..|:.|:.:|.:..|..:
Human   193 WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMF 257

  Fly   185 TISRMIVGATTSGVFLVAYVIA---LEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWL 246
            .|:|.:.|:..:|..::...:.   ||.:...:|..|||....|::.|.||.|...|.|.|||||
Human   258 AITRTLTGSALAGFTIIVMPLGEAELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWL 322

  Fly   247 QIAITL---PGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVA 308
            .:|:||   ||:|.|   |.:||||||||.:|...||...:...|:.|...|..:.:.|   |..
Human   323 LLAVTLPCAPGILSL---WWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQ---EAV 381

  Fly   309 EKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMIS 373
            .|....|....:|  :..||.|.|.||..:|.....||..:..|||||.:.:.||.|.....::.
Human   382 SKVAAGERVVRRP--SYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLF 444

  Fly   374 GAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYG 438
            ||||:|...|:..::...|||....||::...::....:.|.|||.......|::||....:::.
Human   445 GAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFT 509

  Fly   439 TIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLL 503
            |.|:|::|.:|||:|..|:|.:::|.|:||.|||...||..:|..||.:..|.::|.|...:|||
Human   510 TAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLL 574

  Fly   504 PETLNKPMPETIEDGENFGKKPAPQETAEE 533
            |||....:||||:|.|   :|.||....||
Human   575 PETRQAQLPETIQDVE---RKSAPTSLQEE 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	176/584 (30%)
		MFS	135..491	CDD:119392	122/361 (34%)
SLC22A7	XP_011512558.1	2A0119	11..585	CDD:273328	176/584 (30%)
		MFS	206..563	CDD:119392	123/364 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870