DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a2

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	190/538 - (35%)
Similarity:	291/538 - (54%)	Gaps:	31/538 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL-W 66
            :|:::.|:|||..:||:|:.|||..::|.:...:..|||...||:||.    :..|.|.|... |
Frog     4 FDELLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVPDYRCV----SAGIPEPSNECEW 64

  Fly    67 NLSY--PEN-------ERCSYYDVDYTEEYL---NGSIPRSSNETKTCSSYVYDRSKYLNSAVTE 119
            .|:|  |..       .:|..||||:....|   |.|:..:|....|.....:|.:...:|.|||
Frog    65 TLNYTGPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNCKDGWDYNTTGSSLVTE 129

  Fly   120 WNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSY 184
            :||||..|.......|...:|..:|.||.|.::|:.||||...:|:::..|||:|.|.||.|...
Frog   130 FNLVCGDSWKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILITGIFGILMAFAPNYPLV 194

  Fly   185 TISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIA 249
            ...|.|.|..:.|.:|..|::..|.||..:|...|:..|..|:||.:|.:|.||.:..|||||:.
Frog   195 VTFRFIQGFVSKGCWLSGYILVAEFVGLEHRRTVGIVYQAAFTVGLLLLSGVAYVLPHWRWLQMT 259

  Fly   250 ITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQD 314
            :|:|...||.|||.:|||.|||:.:.||.||..||...||:|...||         :..|....|
Frog   260 VTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVP---------DFLESLTAD 315

  Fly   315 EMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIP 379
            |.|..:...:..||:|.|.:|:.||::.:.||..:.||.|...:..:...|...:|.||..||.|
Frog   316 EEAGEKQVPSFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAENIYFDFFISALVEFP 380

  Fly   380 GYTLLLFTLNRWGRRS--ILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYI 442
            ...|::.|::|.|||.  ::|  .::.||:.|.|.|:|...:|||:..:.:.::.||.||..:.:
Frog   381 SAILIIVTVDRVGRRYPWLVC--CIITGITCLITAFIPHGYSWLIITLSCVSRMGITVSYEMVCL 443

  Fly   443 FSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLIICGALSLTAGLLSLLLPET 506
            .:||.:||.:||:|:...|.:..:||::.|::.. |..||:.||||:...|:..:|:|...||||
Frog   444 VNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAAIWQELPLIVFAVLATVSGILVYFLPET 508

  Fly   507 LNKPMPETIEDGENFGKK 524
            ..:.:|||||:.||..|:
Frog   509 KGRALPETIEEAENLHKQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	181/518 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/358 (36%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	181/518 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11506
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010