DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a31

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_012817743.1	Gene:	slc22a31 / 100485676	XenbaseID:	XB-GENE-6048942	Length:	558	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	140/529 - (26%)
Similarity:	227/529 - (42%)	Gaps:	51/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPENE 74
            :|.||.|.:.:.....||.:..|....:.:...|.|.::|     .|...:..|.
Frog    11 VGGFGRYTRLLAAATWLPNVALAMGFFSELMYTAVPSYQC-----QGVSGDPCPG---------- 60

  Fly    75 RCSYYDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNS-AVTEWNLVCSRSLLSATSDSLF 137
                          |.|...|||:::.| ..:.:....:||| .||:|.|:|.|..........:
Frog    61 --------------NSSWENSSNQSQHCPGGWHFQAQGWLNSNIVTQWELLCDRQWKVPLEKISY 111

  Fly   138 MLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVA 202
            ::|.|||.:|||.:.|:|||:..|..:||:.|..||.......|||:...|...||..:|:||..
Frog   112 LVGWLLGYIIFGCICDRLGRRAAFIGALVMALPLGVAVTFTSSYFSFLPLRAGFGAALAGMFLSF 176

  Fly   203 YVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYW----I 263
            |:..:|:...|.||...:....|:..|.:|..|.|....|||.||.:|| ..|:.|..||    :
Frog   177 YISRVELCSPSQRLMVTMIGGFFWVAGELLLPGMAVLCSDWRVLQGSIT-GTLMLLGVYWCGHTL 240

  Fly   264 IPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDL 328
            .|||.||||...:.::....:...|:.|.:.:..:...|  |.|.  .:.|.:....|....:.:
Frog   241 YPESPRWLLATQQVEQCKSELHMFARANGINIGEDASGQ--DHVF--TEIDSLCEGFPRPQYYSI 301

  Fly   329 LRYPNLR---RKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNR 390
            ......|   |..|::.|..|:..|:....:.|....|  ..:.:.:....||....|:...::.
Frog   302 CSIFGTRLIWRNALILGFTAFIGCGIRPCFARNLQVFG--PYIPYFLQAGSEIVACILICICVSH 364

  Fly   391 WGRRSI-LCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYI---FSAEQFPTV 451
            .||||: |..|::....|||.......|:  .|.|..:|..:....|:..:.:   ::.|..|||
Frog   365 CGRRSVLLLFTILTGFCSLLLLALTQLDL--FIEASIVISVVGSLCSHAVVMLSVFYACEVLPTV 427

  Fly   452 VRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIE 516
            :|..|||....:..:|....|:::|..:....|..::..:..:.:.|..||||||..|.:|||:.
Frog   428 IRGSGLGLIMGINMLGRASLPFIELQHKSGYFLYHVVLSSFCILSVLSLLLLPETKRKSLPETLR 492

  Fly   517 DGENFGKKP 525
            .|||..:.|
Frog   493 HGENLRRPP 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	134/515 (26%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	98/366 (27%)
slc22a31	XP_012817743.1	MFS	110..470	CDD:119392	98/368 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010