DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	571	Identity:	217/571 - (38%)
Similarity:	314/571 - (54%)	Gaps:	68/571 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |.:|.::..:|.||.|||.:|..:|||.|...||.:|.||..|.|..||     .||...:..
Zfish     1 MNFDQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRC-----RGSTSGMED-- 58

  Fly    66 W----NLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSS---------------YVYDRSK 111
            |    |||                 ::|.||.|.:.....|::               :||....
Zfish    59 WTFTSNLS-----------------HVNLSISRLAGFADACTAASGVNRSARTNCETGWVYSHEV 106

  Fly   112 YLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAA 176
            :.::.||||:|||.:..||:...|::|||:|:|:::||.|:|:.||:.....||.||.:|||.||
Zfish   107 FQSTTVTEWDLVCDKRGLSSLGSSIYMLGLLVGAVVFGAMADRYGRRFAMLVSLALQTVFGVAAA 171

  Fly   177 VAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIH 241
            .||.:..|...|.|:|.|.|||.:.|:|:..|...:..|:.||:....||..|:||.||.|:.|.
Zfish   172 FAPNFPVYVGLRFIIGMTVSGVIINAFVLGTEWTCTQRRMLAGIFTDYFFGFGYMLLAGVAFLIR 236

  Fly   242 DWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDE 306
            |||.||:||:.||.||:.|.|::|.||||||:..||:||..::.|||..|...:|..:..:..:.
Zfish   237 DWRKLQLAISAPGFLFIFYIWVLPHSARWLLVNNRKEEAIDLLRKAASVNGRTLPPTVQVERYES 301

  Fly   307 VAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFM 371
            ...:.|.          ||.||||.|.:|::.|::|:.||||..||||||...::||.:..:...
Zfish   302 PQGRSKY----------TVVDLLRTPQMRKRALILFYIWFVNVLVYYGLSLGVSDLGADLYLTQF 356

  Fly   372 ISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSS 436
            :.|.||||..||:|..| ...|:..|...::|.|.:.|.|:.:|:|...:..|.||:||..||:|
Zfish   357 MFGLVEIPARTLVLVLL-PCSRKIPLSVFLVVGGGACLLTLTLPADSAHVRTALAMVGKFGITAS 420

  Fly   437 YGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSL 501
            :..||::|||.||||:|..|:|.|||.||:||:|||.:.|||.....:|::|.|:..|.|..|:|
Zfish   421 FAIIYVYSAELFPTVLRQTGIGVSSMFARMGGVLAPLINLLGRHTPVVPMLIFGSTPLLAAALAL 485

  Fly   502 LLPETLNKPMPETIEDGENF-----GKKP-----APQETAEEGGTQELSGM 542
            .||||..:|:|::|.|.|..     |:.|     :|..|  ||  |||..:
Zfish   486 ALPETARQPLPDSIHDTEKSTLKYDGQIPVQASQSPNNT--EG--QELQSL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	203/521 (39%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	150/355 (42%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	202/520 (39%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	147/345 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H80237
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2060
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm6383
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930