DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and slc22a5

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	580	Identity:	182/580 - (31%)
Similarity:	284/580 - (48%)	Gaps:	80/580 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG-YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPH 64
            || ||:....||:.||:..|::.||.|..|....|.|..||:.|.|..||.:
Zfish     1 MGNYDEDTAFLGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHRCRV------------- 52

  Fly    65 LWNLSYPENERCSYYDVDYTEEYLNGSIP---------------RSSNETKT------------- 101
                           ||:.||::|..|.|               |.|.:|.|
Zfish    53 ---------------DVNLTEDWLEASAPTETLSNGDLQVSQCWRYSLQTLTNLSGQGYSPGQIN 102

  Fly   102 --------C-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGR 157
                    | ..:||....|.::.|:||:|||........:.|...:|.||||::.||:||:.||
Zfish   103 ITDIPRERCEDGWVYSADVYHSTIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGR 167

  Fly   158 KPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVA 221
            |...|.||..:.:.....:.:|.:..:.:....:||....:::.|:|:..|::..|.| ||..:.
Zfish   168 KKVLFGSLAAEALLMFAQSFSPSWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLG 232

  Fly   222 MQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEK 286
            ..:.:.||:||....|:.|..||.|...::...::::..:|:||||.||||.:|...|:..|:..
Zfish   233 AFLHYCVGYMLLPWVAFAIRHWRTLLRVLSGLTVVYIPLWWLIPESPRWLLSQGHVQESEAILRD 297

  Fly   287 AAKENKVEVPNEIYEQ-LVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWF-VNS 349
            ||::|:|..|..|::| .:.|.|.:|.:         .:..|:||..|:||.|.:....|. :|.
Zfish   298 AARKNRVPAPEVIFKQSQIKEAAFQKSK---------YSALDVLRTSNIRRTTFMCLLLWMAINI 353

  Fly   350 GVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFV 414
            | |:|||.||.||.|:..:|..:|...|:|.|.:..|.|....||.:|...:::.|..||....:
Zfish   354 G-YFGLSLNTTNLSGDPFLNCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGFLLLVQLI 417

  Fly   415 PSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGE 479
            |..:..|.:|..|.||...|.|:..:||::||.:|||:||:|:|..|..||:|.|.|||:..||.
Zfish   418 PDRLQTLALALEMAGKFGFTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGT 482

  Fly   480 IWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPA-PQETAEEGGTQE 538
            ..|.||.::.|:|::||.|.:|.||||..|.:||.:|..:.....|. .:::.|:||..|
Zfish   483 FNRHLPYVLMGSLTITASLANLFLPETFGKVLPENLEQMQKSRSFPGRDKQSVEDGGGGE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	170/542 (31%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	121/358 (34%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	169/541 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840