Protein Alignment Orct2 and SV2B

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_055663.1
• Gene: SV2B / 9899
• HGNCID: 16874
• Length: 683
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 132/689 - (19%)
• Similarity: 219/689 - (31%)
• Gaps: 276/689 - (40%)

  Fly     5 EAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLS 69
            |.|:.....||:|.|::|::.|..:.....    ||::               |:.||:
Human    96 ETIMDECGHGRFQWILFFVLGLALMADGVE----VFVV---------------SFALPS------ 135

  Fly    70 YPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSD 134
             .|.:.|                 .||::.......||
Human   136 -AEKDMC-----------------LSSSKKGMLGMIVY--------------------------- 155

  Fly   135 SLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVF 199
                ||::.|:.:.|.|:||.|||.:|..||.:...|..|:.....|..:.|.||:.|....|..
Human   156 ----LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGAL 216

  Fly   200 LVAYVVAMEMVGPDKR----LYAGIFVM--------MFFSV------GFMLTAVFAYFVHDWRWL 246
            .:.:....|.:..:||    .:.|||.|        |.:|:      ||.:..  .|..|.||..
Human   217 PIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGT--NYHFHSWRVF 279

  Fly   247 QIALTLPGLIFMFYYWIIPESARWLLLKGRKDCA--------IANMQKAARFNKV-EISDEALSE 302
            .|...||..:.|.....:|||.|:||..|:.|.|        ..||:......|| .:|:....:
Human   280 VIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPK 344

  Fly   303 LLDEGENSEEKA---------------KQKLEDQELDEGPPPSVWD--LFCYPN-LRRKTLLIFL 349
            .:||....:...               ||              |||  |:|... .|..||::.:
Human   345 QMDEFIEIQSSTGTWYQRWLVRFKTIFKQ--------------VWDNALYCVMGPYRMNTLILAV 395

  Fly   350 DWLVTSGVYYGLS-WNTSNL----------------GGNV---LLNFVISGAVE----------- 383
            .|...:..||||: |....:                |.:|   .:||.:...:.
Human   396 VWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFT 460

  Fly   384 ---------------------------------IPAYI--------------------------- 388
                                             |.:.|
Human   461 RMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEG 525

  Fly   389 ----------FLLLTLNRWGRRSILCGCLV------------MAGLSLLATVIIPQRMHTLIVAC 431
                      ||:..::..|..|:|.|.::            |.|.|:|.:.          |.|
Human   526 CHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISA----------VCC 580

  Fly   432 ----------AMLGKLAI-----TASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAP--F 479
                      ||:|...:     .|::..:.:.:.|.:||..|..|.|..:.:.:...::..  |
Human   581 FFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIF 645

  Fly   480 LNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPML 518
            .:|:. |.|.:|:|:..:..:..||::|.||||..:.::
Human   646 ASFVG-ITKVVPILLAAASLVGGGLIALRLPETREQVLM 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	130/683 (19%)
SV2B	NP_055663.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		synapt_SV2	8..683	CDD:130366	132/687 (19%)