Protein Alignment Orct2 and SLC22A8

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001171661.1
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 169/573 - (29%)
• Similarity: 282/573 - (49%)
• Gaps: 43/573 - (7%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:.|.:..:|..|.:|.:...::.|..:.:|.|.|..:|..|.|...|..|      ::..|..
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPP------HNASTGP 59

  Fly    66 WNLSYPEN---ERCSYYDVDYTEEYLNGSIPRSSNET-KTC-SSYVYDRSKYLNSAVTEWNLVCG 125
            |.|....|   |||..:     ....|.|:|..:... :.| ..:||:.:|  :|.||||:|||.
Human    60 WVLPMGPNGKPERCLRF-----VHPPNASLPNDTQRAMEPCLDGWVYNSTK--DSIVTEWDLVCN 117

  Fly   126 RDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLM 190
            .:.:...:.|:||.|:|:|.:|.|.|||::||:|||..|.::....|..|..:|.:..|...|.:
Human   118 SNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFL 182

  Fly   191 VGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGL 255
            .|...||:.|...::.:|.|....|......:...::.|..:....||.:..|||||:.:::|..
Human   183 CGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFF 247

  Fly   256 IFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALS----ELLDEGENSEEKAKQ 316
            :|....|..|||.|||:|.|:...|:..:::.|.||..:...|.||    :|..:.|.|..|||.
Human   248 VFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKY 312

  Fly   317 KLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGA 381
                         :..|||..|.|||.|..:.|.|..|...||.|:......|.|:.:..:|.|.
Human   313 -------------TASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGG 364

  Fly   382 VEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTV 446
            |::||....:|:|:..||.:.....|::||.::||...:|..:.|:....|:.||..:::|:..:
Human   365 VDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCL 429

  Fly   447 YIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPE 511
            :::::|.:|||:|...:|.:::..|:..|::|.:.....:...:|.:|.|...|:.|..:|.|||
Human   430 FLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPE 494

  Fly   512 THNKPMLETIADGERF---GKKTKADVYLETGQELRAPEAQPLKGSGETNGST 561
            |.|:|:.|||.|.|.:   .||.|.:..:|     :|.:..||:..|...||:
Human   495 TLNQPLPETIEDLENWSLRAKKPKQEPEVE-----KASQRIPLQPHGPGLGSS 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	152/517 (29%)
		MFS	127..503	CDD:119392	110/379 (29%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	152/517 (29%)
		MFS	96..493	CDD:119392	123/411 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542		9/31 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980