Protein Alignment Orct2 and SLC22A6

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 176/581 - (30%)
• Similarity: 290/581 - (49%)
• Gaps: 41/581 - (7%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:::.:..:|..||:|:|...|:.|..:.:|.|.....|..|.|...|..|.:...|.:....:
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEV 65

  Fly    66 WNLSYPEN-----ERC-SYYDVDYTEEYLNGSIPRSSNETKTCS-SYVYDRSKYLNSAVTEWNLV 123
            |   .|.:     |.| .:....:...:|||:....:..|:.|: .::||.|.:.::.||||:||
Human    66 W---LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLV 127

  Fly   124 CGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFAR 188
            |....:...:.||:|:|||||::|||.|:|:.||:.:|..:.:...:.|..|..||.:..|...|
Human   128 CSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFR 192

  Fly   189 LMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLP 253
            |:.|...:|:.|....:.:|.:....|...|..:...:|:|..|.|..||.|..||.||:.::.|
Human   193 LLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAP 257

  Fly   254 GLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKL 318
            ...|..|.|...|||||....||.|..:..:|:.||.|               |:. ||.||..:
Human   258 FFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARIN---------------GKR-EEGAKLSM 306

  Fly   319 E------DQELDEGP-PPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNF 376
            |      .:||..|. ..|..:|...|.||...|.:.:.|..||..||||..:....|.::.|..
Human   307 EVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQ 371

  Fly   377 VISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITA 441
            ||.|||::||.:...|.:|..|||......|::||:.:|...:|||....:..:.|:|||..:.|
Human   372 VIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAA 436

  Fly   442 SYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLS 506
            |:..:::::.|.:||::|...:|..|.:||:..:::|.::..|.::..:||.|.|::.:.|..::
Human   437 SFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVT 501

  Fly   507 LLLPETHNKPMLETIADGE-RFGKKTK-ADVYLETGQELRAPEAQ-----PLKGSG-ETNG 559
            :|||||..:|:.:|:.|.| |:....| |.:|...|::.|..:..     ||:.|. |.||
Human   502 VLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNG 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	160/522 (31%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	160/522 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563		11/38 (29%)