DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	172/559 - (30%)
Similarity:	286/559 - (51%)	Gaps:	51/559 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH- 64
            ||:::.:..:|.||.:|.....|:.|..:.:..|.|..||:.|.|...||||   |:..:| :|
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALP---GAPANL-SHQ 61

  Fly    65 -LW-----------------NLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCS-SYVYDRS 110
             ||                 ..:||:    :..:|....|..|...|.....|..|| .:.||||
  Rat    62 DLWLEAHLPRETDGSFSSCLRFAYPQ----TVPNVTLGTEVSNSGEPEGEPLTVPCSQGWEYDRS 122

  Fly   111 KYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLA 175
            ::.::..|||:|||.:..:...:.:.|.:|||:|::|:|.|||::||:.:|..:.|..::.|:::
  Rat   123 EFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMS 187

  Fly   176 GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFV 240
            ..:..|..:...|.:.|:..:|..::...:.:|.:..:.|..||:...:|:|.|.:|.|:..|.:
  Rat   188 AASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLI 252

  Fly   241 HDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-----KVEISDEAL 300
            ..||||.:|.|||.:..:...|.:||||||||.:||.:.|...:...|:.|     :..:|.|||
  Rat   253 RSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEAL 317

  Fly   301 SELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNT 365
            :.::     :.|:|.|:           ||..|||....||..:|...:.|...:..||||:.:.
  Rat   318 NNVV-----TMERALQR-----------PSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDV 366

  Fly   366 SNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVA 430
            |.||.||....::.||||:|:.|.:...:.|.|||....|.|:.|.|:...::::.....:.|.|
  Rat   367 SGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITA 431

  Fly   431 CAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLIC 495
            ..::||....|::.|.|:|::|.:|||:|...||..:::.|:...:||....|..:|..||.:..
  Rat   432 LVVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAY 496

  Fly   496 GSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTKAD 534
            |.:.|||...:||||||....:.|||.|.||  |.|:.:
  Rat   497 GGIALVAACTALLLPETKKAQLPETIQDVER--KSTQEE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	162/533 (30%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	115/380 (30%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	162/533 (30%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	118/382 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840