DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	169/565 - (29%)
Similarity:	276/565 - (48%)	Gaps:	39/565 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:.|.:..:|..|.:|.:...|:.|..:.:|.|.|..:|....|...|..| .|.|     ...
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPP-PNAS-----IGP 59

  Fly    66 WNLSYPEN---ERCSYYDVDYTEEYLNGSIPRSSNE-TKTC-SSYVYDRSKYLNSAVTEWNLVCG 125
            |.|....|   |:|..:     ....|.|:|..:.. |:.| ..::|:.::  ::.|.||:|||.
  Rat    60 WVLPLDPNGKPEKCLRF-----VHLPNASLPNDTQRATEPCLDGWIYNSTR--DTIVIEWDLVCS 117

  Fly   126 RDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLM 190
            .:.:...:.|:||.|:|:|..|.|:|||::||||||..|.::....|..|..:|....|...|.:
  Rat   118 SNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFL 182

  Fly   191 VGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGL 255
            .|.:.||:.|...::.:|.|....|..:...:...:::|..:.:..||.:..|||||:..:.|..
  Rat   183 CGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFF 247

  Fly   256 IFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN--KVEISDEALSELLDEGENSEEKAKQKL 318
            ||....|.:|||.|||:|.|:...|:..:|:.|.||  |.|.....:.||....:.....||.|.
  Rat   248 IFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAKVKY 312

  Fly   319 EDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVE 383
                       .:.|||....|||.|..:.|.|..|...||.|:......|.|:.:..:|.|.|:
  Rat   313 -----------GLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVD 366

  Fly   384 IPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTVYI 448
            |||....:|:|:..|||......|::||.::||.:.:|..|..|..|.|:.||..::.|:..:::
  Rat   367 IPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFL 431

  Fly   449 FSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETH 513
            :::|.:|||:|...:|.:::.||:..|:||.:.....:...:|.:|.|:..|:.|..:..|.||.
  Rat   432 YTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETL 496

  Fly   514 NKPMLETIADGERFGKKTKADVYLETGQELRAPEAQ---PLKGSG 555
            |:|:.|||.|.:.:.|:.:     :|.||..|.:|.   |||..|
  Rat   497 NRPLPETIEDIQNWHKQVQ-----KTKQESEAEKASQIIPLKTGG 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	153/515 (30%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	116/377 (31%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	153/515 (30%)
		MFS	124..492	CDD:119392	117/378 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536		8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950