Protein Alignment Orct2 and slc22a3

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001107932.1
• Gene: slc22a3 / 797890
• ZFINID: ZDB-GENE-080204-92
• Length: 554
• Species: Danio rerio
• Alignment Length: 579
• Identity: 169/579 - (29%)
• Similarity: 281/579 - (48%)
• Gaps: 53/579 - (9%)

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRC---ALPFENGSSYDLPTH 64
            :||.:.|.||||.|||.|..|..|..:.:||..:..|||...||..|   :|..:.|.|.:   .
Zfish     4 FDELLQHAGDFGFYQKRISVLGSLPILLLAFVLIGVVFLGYTPDHWCKTASLQEKCGFSEE---Q 65

  Fly    65 LWNLSYPEN------ERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSA------- 116
            :.:|:.|..      .:|    |.:.:...|||       ..:|:..:::.|.:|::.
Zfish    66 VRDLTVPRTGARGAFSKC----VKFDDALRNGS-------ALSCNISIFNNSTHLSACNEGWTFN 119

  Fly   117 ------VTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLA 175
                  |||::|||...::|..:......|..:|::|.|.|:|::|||....||:....:.|...
Zfish   120 ENRTTIVTEFSLVCEDSWLADLNQVSLAGGFFIGALVTGYLADRFGRKSCFIASIFGLGVSGTCI 184

  Fly   176 GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFV 240
            ..:|.|....|.|.:.|....|.:...||:.:|..|.:.|.:..:....|:|:|.:|....||::
Zfish   185 IFSPYYPLLLFFRCLQGFFAKGAWTATYVLIIEFFGSNNRKFVSVMSRTFYSLGLVLLPALAYYI 249

  Fly   241 HDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLD 305
            ..||.||:|:|||..||:.|:|:||||.||||.:.:...|::.::..|:.||     .:|.|...
Zfish   250 PSWRNLQLAMTLPTFIFLIYHWVIPESPRWLLSQRKTKEALSIVKSIAKCNK-----RSLPEDFH 309

  Fly   306 EGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGG 370
            |.:...||.::.:.         ||..|||..|.:|:.|.::...|...:.|:.||.......|.
Zfish   310 EMDLLIEKQEEIMR---------PSYKDLFKTPKMRKHTFILIYAWFTGAVVFQGLVLRLGITGD 365

  Fly   371 NVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLG 435
            ||.|:|:||..||:|..:.....::|.|||.::.....:.|.:.||...|...:..|....|::|
Zfish   366 NVFLDFLISAVVELPTGLIFYFLVDRIGRRPLMATVNFIGGAACLAVPFISPNISWLRRTIAIVG 430

  Fly   436 KLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICGSLT 499
            :||:.....||...:.|.:||.:||:.:...|..:.|..::|||:.: ||:||:.||||:.|.::
Zfish   431 RLAVAIGNETVNFANTELYPTPLRNLGVSVCSSASDIGAVVAPFILYRLASIWQELPLLVYGVMS 495

  Fly   500 LVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETN 558
            ::...|.:||||.....:.||:.|.|....:.|...  :.|.:.......|:|...:|:
Zfish   496 VLYSGLVMLLPEMKGVDLPETVDDVENLRSRHKRKE--KDGAQFPEINIVPMKAVEKTS 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	157/531 (30%)
slc22a3	NP_001107932.1	MFS_SLC22A1_2_3	105..506	CDD:340937	125/414 (30%)