Protein Alignment Orct2 and Slc22a23

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001028339.1
• Gene: Slc22a23 / 73102
• MGIID: 1920352
• Length: 689
• Species: Mus musculus
• Alignment Length: 640
• Identity: 150/640 - (23%)
• Similarity: 255/640 - (39%)
• Gaps: 103/640 - (16%)

  Fly     1 MGYDEAII-HLGDF-GRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLP- 62
            :.||.::: .||.. |.|||.:..|..:.::.:.|.:.:..|||.:|||.|.   ..|...:|.
Mouse    78 LDYDGSVLPFLGGLGGGYQKTLVVLTWIPALFIGFSQFSDSFLLDQPDFWCR---GAGKGTELAG 139

  Fly    63 ---THLW----NLSYPENERCSYYDVDYTEEYLNG-------SIPRSSNETKTCSSYVYD---RS 110
               |..|    |.:.|.....|......|....|.       |.|...|....|..:.:|   |:
Mouse   140 ATVTGRWGDMGNWTSPSATPFSTASWGTTSNRSNSSDTPPLPSPPGKGNNDSNCDCHAWDYGIRT 204

  Fly   111 KYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLA 175
            ..:.:.|::|:|||...:....:....::|::.|.::.|.::|..||:|:|..|.:..::||:..
Mouse   205 GLIQNVVSKWDLVCDNTWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSTIFILIFGLTV 269

  Fly   176 GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFV 240
            .::.....::..|...|...:|:.|..|.:.:|:..|.||....:........|..|....|...
Mouse   270 ALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFIITMVASFVAMAGQFLMPGLAALC 334

  Fly   241 HDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARF-----NKVEISDEAL 300
            .||:.||..:..|.|:.:.|:.|.|||.|||:       |....:.|.:.     .|..:|.|
Mouse   335 RDWQVLQALIICPFLLMLLYWSIFPESLRWLM-------ATQQFESAKKLILYLTQKNCVSPE-- 390

  Fly   301 SELLDEGENSEEKAKQKLEDQELDEGPPP-SVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWN 364
                     |:.|......::||...|.. .:..:....||.:..:::.::.|...|:::  .:.
Mouse   391 ---------SDIKGVMPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHH--CFA 444

  Fly   365 TSNLGGNV----LLNFVIS----GAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIP 421
            .|.:|..|    |.||...    .::.:.:.:.:.|.:...|||.   |.|:...|:.||: ::.
Mouse   445 RSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVKFLGRRG---GLLLFMILTALAS-LLQ 505

  Fly   422 QRMHTLI----------------------------VACAMLGKLAITASYGTVYIFSAEQFPTVV 458
            ..:..||                            :|.:::|..|..|.......|.||..|||:
Mouse   506 LGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVI 570

  Fly   459 RNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIAD 523
            |...||.....|....:.||.:.........|..:|....||:..:..|||||:.|:.:.|.||:
Mouse   571 RCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRNQNLPENIAN 635

  Fly   524 GERFGK------KTKADVYLETGQELRAPEAQPLK-----GSGETNGSTIANGHK 567
            ||.:.:      |......|.|..||:  :...|.     |.|...|:| |||.|
Mouse   636 GEHYTRQPLLPHKKGEQPLLLTNAELK--DYSGLHDVAAVGDGLPEGAT-ANGMK 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	128/569 (22%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..188		4/25 (16%)
		MFS_SLC22A23	187..608	CDD:341002	95/444 (21%)