Protein Alignment Orct2 and SLC22A5

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 184/596 - (30%)
• Similarity: 308/596 - (51%)
• Gaps: 84/596 - (14%)

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWN 67
            |||....||::|.:|::|:||:..:.||..|..|:.|||:|.|:.||.:|    .:.:|.:...|
Human     4 YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----DAANLSSAWRN 64

  Fly    68 LSYPENER--------CSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .:.|...|        |..|                 |||.      |.:     |.::| ..:.
Human    65 HTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDL------GQL-----EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTE------------------------WNLVCGRDFMAATSDSLFMLGVLLGSIV 147
            :.:..||::.|||                        |||||..|:.|..:.|||.:||||||.:
Human   119 FSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFI 183

  Fly   148 FGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGP 212
            .|||||::|||.:||.::.:|..|..|...:..:..:....::||......::.|:|:..|::|.
Human   184 SGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGK 248

  Fly   213 DKR-LYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGR 276
            ..| :::.:.|.:|::.|:|:..:||||:.|||.|.:|||:||::.:..:|.||||.|||:.:||
Human   249 SVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGR 313

  Fly   277 KDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLR 341
            .:.|...::|||:.|.:.:.    |.:.|..|         |:|....:....::.||....|:|
Human   314 FEEAEVIIRKAAKANGIVVP----STIFDPSE---------LQDLSSKKQQSHNILDLLRTWNIR 365

  Fly   342 RKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGC 406
            ..|::..:.|:..|..|:|||.:|.||.|::.:|..:|..||:|||:...|.|....||..:...
Human   366 MVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATA 430

  Fly   407 LVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVAR 471
            |.:.|..||...::|..::.|.....|:||..:||::..||:::||.:||||||:.:|.:|..:|
Human   431 LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASR 495

  Fly   472 ISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETI-----ADGERFGKKT 531
            :..:::|:..:|....:.||.::.||||::..:|:|.|||:...|:.:||     ..|.:..|..
Human   496 LGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTP 560

  Fly   532 KADVYLETGQE 542
            .....|:.|||
Human   561 SHTRMLKDGQE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	172/559 (31%)
		MFS	127..503	CDD:119392	126/376 (34%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	172/559 (31%)
		MFS	162..534	CDD:119392	128/384 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8592
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770