DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and SLC22A4

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens

Alignment Length:	570	Identity:	195/570 - (34%)
Similarity:	308/570 - (54%)	Gaps:	66/570 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWN 67
            |||.|..||::|.:|::|:||:..:.||..|:.::.|||...|:.||.:|    .:.:|.:...|
Human     4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP----DAANLSSAWRN 64

  Fly    68 LSYPENER--------CSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .|.|...|        ||.|                 |||.      |.:     |.::| ..:.
Human    65 NSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDL------GQL-----EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLF 171
            :.:..||::.||||||||..::....:.|||.:||||||.|.|||||::|||.:|||::.:|..|
Human   119 FSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGF 183

  Fly   172 GVLA--GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLT 233
            ..|.  .::.|.||..|  ::||......::||:::..|::|...| :::.:.|..||:||:||.
Human   184 SFLQIFSISWEMFTVLF--VIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLL 246

  Fly   234 AVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDE 298
            .:||||:.|||.|.:|||:||::.:..:|.||||.|||:.:.|...|...:||||:.|.:.:.
Human   247 PLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVP-- 309

  Fly   299 ALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSW 363
              :.:.|..|......:||           ..:.|||...|:...|::..|.|::||..|:.||.
Human   310 --AVIFDSVEELNPLKQQK-----------AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSL 361

  Fly   364 NTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI 428
            :..||.|:..||..:|..:||||||...|.|....||.|:...|...|..||...::|...:.|.
Human   362 DAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLS 426

  Fly   429 VACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLL 493
            :...||||..||:::..:|:|:||.:||:|||:|:|..|..:|:..::||:..:|....:.||.:
Human   427 IGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYI 491

  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETIADGE-----RFGKKTKADVYLE 538
            :.||||::.|:|:|..||:....:.||:...:     |.||||:..:..|
Human   492 VMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	182/537 (34%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	137/378 (36%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	182/537 (34%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	150/401 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8592
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770