Protein Alignment Orct2 and SLC22A2

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 187/569 - (32%)
• Similarity: 289/569 - (50%)
• Gaps: 47/569 - (8%)

  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP------FENGSSYDLP 62
            |:.:.|.|:|..:||.::||:.|.|...|...:..|||...||.||..|      ...|.|   |
Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWS---P 67

  Fly    63 THLWNLSYP--------ENERCSYYDVDYTEEYLNGSIPRSSNETK-------TC-SSYVYDRSK 111
            ....|.:.|        ...:|..|:||:.:...:...|.:|.:|.       .| ..:||:...
Human    68 AEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPG 132

  Fly   112 YLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAG 176
              :|.|||:||||...:|.....|...:|..:||:..|.::|::|||..|..:::|....|||..
Human   133 --SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMA 195

  Fly   177 VAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVH 241
            ::|.|......||:.|..:...:|:.|::..|.||...|...|||..:.::||.::.|..||.:.
Human   196 ISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALP 260

  Fly   242 DWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDE 306
            .|||||..::||...|:.|||.||||.|||:.:.:...|:..::..|:.|...: ..:|..|
Human   261 HWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSL-PASLQRL--- 321

  Fly   307 GENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGN 371
              ..||:..:||.         ||..||...|.:|:.|:::..:|..:|.:|.||..:....|.|
Human   322 --RLEEETGKKLN---------PSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDN 375

  Fly   372 VLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGK 436
            :.|:|..|..||.||...::||::|.|||.......::||.:.||:|.||..:..|.:..:.||:
Human   376 IYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGR 440

  Fly   437 LAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICGSLTL 500
            :.||.:|..|.:.:||.:||.:||:.:...|.:..|.|::.|||.: |..||..|||::.|.|.|
Human   441 MGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGL 505

  Fly   501 VAGLLSLLLPETHNKPMLETIADGE---RFGKKTKADVYLETGQELRAP 546
            |||.|.||||||..|.:.|||.:.|   |..|..:..:||:. |:|..|
Human   506 VAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQV-QKLDIP 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	174/531 (33%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	174/531 (33%)
		Proline-rich sequence. /evidence=ECO:0000269|PubMed:26979622	284..288		3/3 (100%)