Protein Alignment Orct2 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 179/568 - (31%)
• Similarity: 293/568 - (51%)
• Gaps: 61/568 - (10%)

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPD-FRC------ALPFENGSSYD 60
            :|||:..:|:|||:|:.::.|:|||.:..||..:..|||..:|| :.|      ||....|.|
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWS-- 66

  Fly    61 LPTHLWNLSYPENE---------RCSYYDVDYTEEYLN-----------GSIPRSSNETKTC-SS 104
             |...||.:.|.:.         ||..|.::...:..:           .:.|..|.....| ..
Human    67 -PEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGG 130

  Fly   105 YVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQV 169
            :.|.::.  ::.|:|::|||...:|...:.::..||.|.|:...|..:|:|||..|...|.:...
Human   131 WRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVG 193

  Fly   170 LFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTA 234
            :.||:...||.:..:...|.:.|....|.::..||:..|:||..:|...||.:.|||::|.::..
Human   194 VTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 258

  Fly   235 VFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEA 299
            ..|||:.:|:.:|:|:|||..:|:.|||::|||.|||:.:.:.|.|:..:::.|:.|...:|..
Human   259 GIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSN- 322

  Fly   300 LSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWN 364
            .||:             .:.|:|:..   ||..||...|.:|:.||::...|..::.||.||...
Human   323 YSEI-------------TVTDEEVSN---PSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 371

  Fly   365 TSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIV 429
            ...:|||:.::|.|||.||:|..:.:|||:.|.|||.......::||::.|.|..:|:.:..|..
Human   372 LGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRT 436

  Fly   430 ACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLL 493
            ..|.||:|.||.::..||:.::|.:||.:||..:...|.:....|::||||.| ||.:|..|||:
Human   437 TVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLI 501

  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETIADGERFG----------KKT 531
            |.|.|..:.|.|.:|||||....:.||:.|.|:.|          |||
Human   502 IFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKT 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	168/537 (31%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	168/537 (31%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)