Protein Alignment Orct2 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 161/516 - (31%)
• Similarity: 251/516 - (48%)
• Gaps: 47/516 - (9%)

  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL-WN 67
            |:.:..:|:.|.:||..:.::||.|...|...:..|||...||..|..|    ...:|.... |:
Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQRCGWS 65

  Fly    68 ----LSY------PENE----RCSYYDVDYTEEYLNGSIPRSSNETK-------TC-SSYVYDRS 110
                |:|      |..|    :|..|:||:.:..|:...|.:|..|.       .| ..:|||..
Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTP 130

  Fly   111 KYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLA 175
            .  :|.|||:||||...:......|....|.|.||:..|..:|::|||..|..::::..:.|||.
Human   131 G--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLM 193

  Fly   176 GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFV 240
            ..:|.|.:....||:.|..:.|.::..|.:..|.||...|....|...|.|:||.:.....||.:
Human   194 AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258

  Fly   241 HDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-KVEISDEALSELL 304
            ..|||||:|::||..:|:.|||.:|||.||||.:.|...||..|...|:.| |:..:|..:..|
Human   259 PHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSL- 322

  Fly   305 DEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLG 369
                  ||...:||.         ||..|||..|.||::|.::...|...|.:|.||..:.....
Human   323 ------EEDVTEKLS---------PSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS 372

  Fly   370 GNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAML 434
            ||:.|:|:.|..||||.....|:|::|.||...:....::||.:.|..:.|...:|.|.:....:
Human   373 GNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCV 437

  Fly   435 GKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLI 494
            |::.||.:...:.:.:||.:||.|||:.:...|.:..|.|::.||:.| |..:|:.|||::
Human   438 GRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLIL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	160/509 (31%)
		MFS	127..503	CDD:119392	119/370 (32%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	160/509 (31%)
		MFS	118..484	CDD:119392	125/383 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950