Protein Alignment Orct2 and Slc22a21

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_062697.1
• Gene: Slc22a21 / 56517
• MGIID: 1929481
• Length: 564
• Species: Mus musculus
• Alignment Length: 585
• Identity: 192/585 - (32%)
• Similarity: 312/585 - (53%)
• Gaps: 60/585 - (10%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            :.|||....||::|.:|::|:||:..:.||..|..|:.|||.|.|:.||.:|    .:.:|.:..
Mouse     2 LDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIP----DTVNLSSAW 62

  Fly    66 WNLSYPEN--------ERCSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SS 104
            .|.|.|..        ::|..|                 |||.  |.|         |.:.| ..
Mouse    63 RNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDL--EQL---------EQENCLDG 116

  Fly   105 YVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQV 169
            :.||:..:|::.||||:|||..|:.|..:.|.|.:||||||.:.|||||::|||.|||.::.:..
Mouse   117 WEYDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAMHT 181

  Fly   170 LFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLT 233
            .|..:...:..:..:|....:||......::.|:|:..||:....| ::|.:.|.:||:.|||:.
Mouse   182 GFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVL 246

  Fly   234 AVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDE 298
            .:||||:.:||.|.:|:||||::....:|.||||.|||:.:||...|...::|||:.|.:    .
Mouse   247 PLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGI----V 307

  Fly   299 ALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSW 363
            |.|.:.|..|.:      ||:|....:.....::||...||:|..|::..:.||..|..|:|||.
Mouse   308 APSTIFDPSETN------KLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSL 366

  Fly   364 NTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI 428
            :|.||.||:.:|..:..|||:|||:...|.|....||..:.|.|.:.|..||...::|..:|.|.
Mouse   367 DTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLS 431

  Fly   429 VACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLL 493
            ....|:||..||::|..||:::||.:||||||:.:|.:|..:|:..:::|:..:|....:.||.:
Mouse   432 TTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYI 496

  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETN 558
            :.||||::..:::|..||:....:.|||.:.::..|       |:..|.| :.:..|.:..|..:
Mouse   497 LMGSLTILTAIITLFFPESSGVSLPETIDEMQKVKK-------LKQRQSL-SKKGSPKESKGNVS 553

  Fly   559  558
            Mouse   554  553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	179/535 (33%)
		MFS	127..503	CDD:119392	135/376 (36%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	179/535 (33%)
		MFS	123..513	CDD:119392	144/399 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..564		6/30 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843606
Domainoid	1	1.000	282	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.830