Protein Alignment Orct2 and SLC22A15

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 183/579 - (31%)
• Similarity: 281/579 - (48%)
• Gaps: 70/579 - (12%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLIC-LTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH 64
            |..:||...:|:.|.||..:.||:. |..:.||...:....:.|.|.:.          :||...
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH----------WDLAEL 55

  Fly    65 LWNLSYPENERCSYYDVDYTEEYL--NGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRD 127
            |.|.|:  ..:.:..|..:.:..|  |||         ....:|:..|.: .|..:||.|:..|.
Human    56 LPNQSH--GNQSAGEDQAFGDWLLTANGS---------EIHKHVHFSSSF-TSIASEWFLIANRS 108

  Fly   128 FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVG 192
            :..:.:.|.|..||.:|.|.||||||::|||.:......:.:||.:..|.:|.|..:...|.:||
Human   109 YKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVG 173

  Fly   193 ATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIF 257
            ....|:.|||:|:..|.||......||....:||:||....|:..||:..||.|.|.:.|.|.:.
Human   174 MMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVV 238

  Fly   258 MFYYWIIPESARWLLLKGRKDCAIANMQKAARFNK-----VEISDEALSELLDEGENSEEKAKQK 317
            ......||||.|||..:||...|...:...|:.|:     ..::..|.....:.|
Human   239 FLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETG---------- 293

  Fly   318 LEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAV 382
                        |..|||.|..|...||::...|.|.|.|||||:.:..:|||::..|..:||.:
Human   294 ------------SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLI 346

  Fly   383 EIPAYIFLLLTLN-RW-GRRSILCGCLVMAGLSLLATVIIPQRMHTLIVA------CAMLGKLAI 439
            |||:|...:..:| :| ||:..|...|.:.||:.|..:.:|::..|.:.|      .::||||.|
Human   347 EIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTI 411

  Fly   440 TASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGL 504
            :|::..|||:::|.:|||:|||.||..||.:|:.|::|||:..|..:...||.::.|:..|.:||
Human   412 SAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGL 476

  Fly   505 LSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQE---LRAPEAQPLKGSGETNGS 560
            ||||||||.|.|:|||.:|.:.:.       |...|:|   |:|.:.|.......:.||
Human   477 LSLLLPETLNSPLLETFSDLQVYS-------YRRLGEEALSLQALDPQQCVDKESSLGS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	169/524 (32%)
SLC22A15	NP_060890.2	MFS_SLC22A15	71..469	CDD:340935	137/429 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547		2/7 (29%)