DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	579	Identity:	183/579 - (31%)
Similarity:	281/579 - (48%)	Gaps:	70/579 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLIC-LTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH 64
            |..:||...:|:.|.||..:.||:. |..:.||...:....:.|.|.:.          :||...
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH----------WDLAEL 55

  Fly    65 LWNLSYPENERCSYYDVDYTEEYL--NGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRD 127
            |.|.|:  ..:.:..|..:.:..|  |||         ....:|:..|.: .|..:||.|:..|.
Human    56 LPNQSH--GNQSAGEDQAFGDWLLTANGS---------EIHKHVHFSSSF-TSIASEWFLIANRS 108

  Fly   128 FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVG 192
            :..:.:.|.|..||.:|.|.||||||::|||.:......:.:||.:..|.:|.|..:...|.:||
Human   109 YKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVG 173

  Fly   193 ATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIF 257
            ....|:.|||:|:..|.||......||....:||:||....|:..||:..||.|.|.:.|.|.:.
Human   174 MMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVV 238

  Fly   258 MFYYWIIPESARWLLLKGRKDCAIANMQKAARFNK-----VEISDEALSELLDEGENSEEKAKQK 317
            ......||||.|||..:||...|...:...|:.|:     ..::..|.....:.|
Human   239 FLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETG---------- 293

  Fly   318 LEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAV 382
                        |..|||.|..|...||::...|.|.|.|||||:.:..:|||::..|..:||.:
Human   294 ------------SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLI 346

  Fly   383 EIPAYIFLLLTLN-RW-GRRSILCGCLVMAGLSLLATVIIPQRMHTLIVA------CAMLGKLAI 439
            |||:|...:..:| :| ||:..|...|.:.||:.|..:.:|::..|.:.|      .::||||.|
Human   347 EIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTI 411

  Fly   440 TASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGL 504
            :|::..|||:::|.:|||:|||.||..||.:|:.|::|||:..|..:...||.::.|:..|.:||
Human   412 SAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGL 476

  Fly   505 LSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQE---LRAPEAQPLKGSGETNGS 560
            ||||||||.|.|:|||.:|.:.:.       |...|:|   |:|.:.|.......:.||
Human   477 LSLLLPETLNSPLLETFSDLQVYS-------YRRLGEEALSLQALDPQQCVDKESSLGS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	169/524 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	128/388 (33%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	126/379 (33%)
		MFS_1	111..450	CDD:284993	120/360 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850