DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a28

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001013842.2	Gene:	Slc22a28 / 434674	MGIID:	3645714	Length:	552	Species:	Mus musculus

Alignment Length:	552	Identity:	162/552 - (29%)
Similarity:	265/552 - (48%)	Gaps:	52/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKI-IYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPF-------ENGS 57
            |.:.|.:..:|..||:|.: |.|::.|..:.|. |.....|..|.|:.||..|.       :|||
Mouse     1 MAFQELLNQVGSLGRFQILQISFVLFLVGLVVP-HITMENFTAAIPNHRCWAPILDNDTASDNGS 64

  Fly    58 SYDLPTHLWNLSYPEN-----ERC-SYYDVDYTEEYLNGSIPRSSNE----TKTC-SSYVYDRSK 111
            .......|..:|.|.:     ::| .:....:...:|||:.   |||    |:.| ..:|||||.
Mouse    65 RILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTF---SNETEPDTEPCVDGWVYDRSN 126

  Fly   112 YLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAG 176
            :|::.||||:|||....:.:.:...||:|:.:|:|:.|.|||::|||.||..:|:...:......
Mouse   127 FLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRKFILTCALLQFAITETCVA 191

  Fly   177 VAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVH 241
            .||.:|.|...|.:.|.:...:.:.:.::.:|...|.......:......|:|:|:.|..|:...
Mouse   192 FAPSFFIYCLLRFLAGMSVEPISVNSNLLILEWTNPKFLGMVAVLTSCAASIGYMILAGLAFLFR 256

  Fly   242 DWRWLQIALTLPGLIFMFYY---WIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALS-E 302
            .|..||:|:::|  ||.|:.   | :.||||||::..:....:..::|.|..|.::.|...|: |
Mouse   257 IWHHLQLAMSVP--IFFFFILTRW-MSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGNTLTME 318

  Fly   303 LLDEG-ENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLR-RKTLLIFLDWLVTSGVYYGLSWNT 365
            :::.. :|..|.||:|           .|..|||..|.|| |..:|.|:.:|.|..: :|||.:.
Mouse   319 VVEASMKNELEAAKRK-----------SSPRDLFHTPILRNRICVLSFMRYLFTVSI-FGLSLHL 371

  Fly   366 SNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTL--- 427
            .:|..|::|...:|.|:.|...:.....||..|||......:.:.|:.:|..|.:||.|.||
Mouse   372 QHLSTNIILLRFLSSALGILISVIGHFVLNHMGRRITQLVLMSLRGIFMLTAVFVPQEMQTLRII 436

  Fly   428 -IVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLP 491
             :...|.|..|.:..|  .::|  .|..||.:|...:|...|.......:||....|||....||
Mouse   437 VVTLAAALSSLCMCVS--NLHI--NELLPTTLRATGMGVIGMFGNSGLFLAPLFMLLATYSANLP 497

  Fly   492 LLICGSLTLVAGLLSLLLPETHNKPMLETIAD 523
            .:..|..:::.|....|||||.|:|:.::|.|
Mouse   498 WIFYGGFSILYGFSVFLLPETKNQPLPDSIHD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	158/537 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	107/385 (28%)
Slc22a28	NP_001013842.2	2A0119	11..525	CDD:273328	158/536 (29%)
Slc22a28	NP_001013842.2	MFS	151..516	CDD:119392	109/383 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940