DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and CG8925

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	269/537 - (50%)	Gaps:	62/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLW-NLSYPEN 73
            ||....:|.:...|:.:......||....||.:|..||.||.| ||  ...:....| |:|...|
  Fly   154 LGCLTPWQSMWCALLSIFQAICTFHIFVYVFQIAPKDFWCARP-EN--LMQMSVSEWRNISQSSN 215

  Fly    74 ERCSYYDVDYTE-EYLNGSI---PRSSNETKTCSSYVYDRSKYLNSA---VTEWNLVCGRDFMAA 131
             .|...|||||: .|.|..:   |.::.:......:.::.|....||   |.|::||||||.::.
  Fly   216 -GCLLLDVDYTQVTYENNQLINWPENATDLGYRQCWHFEFSDVDGSAKTLVQEFDLVCGRDILSL 279

  Fly   132 TSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTS 196
            . ::.|::|...|:::.|.:||::||:..|.|.:.||.:||.:...:.....:...|:::|..:.
  Fly   280 V-ETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMSLRVIIGFASM 343

  Fly   197 GVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYY 261
            .|.:|::|:.:|:|....|...||..::..::.::|:|..||.:.|||.||:|::.|.||.:..:
  Fly   344 TVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAISWPWLIMLSIW 408

  Fly   262 WIIPESARWLLLKGRKDCAIANMQKAARFNKVEIS-----DEALSELLDEGENSEEKAKQKLEDQ 321
            :.:|||.||||.:||.|.....:::|||.|....|     .:.|...:.....|..:|...:|.:
  Fly   409 FWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQSPPEATTSVESK 473

  Fly   322 ELD-EGPPPSV---------------WDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGG 370
            .:: :.|.||.               |         |.|.|..:.||....:|:||:.:.|||||
  Fly   474 AVEADAPDPSASGHVNPLLVVFSAKYW---------RTTCLTLVIWLTLIIIYFGLTLHLSNLGG 529

  Fly   371 NVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLG 435
            |:.:|..::|.||..:....:|.:.:.|.|..|.|.:::.||..|||.::..:  |.::|.|.:.
  Fly   530 NIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQ--TGVIALATIA 592

  Fly   436 KLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWK--------PLPL 492
            |..|.|:...:..::|.|:||:|||..:|..::.:.|:.::.|||      ||        ||.:
  Fly   593 KCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFL------WKLEHIDPLLPLNV 651

  Fly   493 L-ICGSLTLVAGLLSLL 508
            : :||.:..||  :||:
  Fly   652 MGVCGLIGAVA--ISLM 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	155/536 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	114/405 (28%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	116/410 (28%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	103/369 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	7.070